Background Eosinophilic airway inflammation is often present in asthma, and reduction of
such inflammation results in improved clinical outcomes. We hypothesised that fevipiprant (…

Previous studies have debated the notion that low blood pressure (BP) during treatment,
particularly diastolic (DBP), is associated with increased risk of cardiovascular disease. We …

Background We aimed to assess the safety and tolerability of different doses of canakinumab
versus placebo in patients with type 2 diabetes mellitus (T2DM). Methods Data were …

We describe a novel collaboration between academia and industry, an in-house data science
and artificial intelligence challenge held by Novartis to develop machine-learning models …

Background The differential diagnosis of asthma and chronic obstructive pulmonary disease
(COPD) poses a challenge in clinical practice and its misdiagnosis results in inappropriate …

Objective The ability to predict impending asthma exacerbations may allow better utilization
of healthcare resources, prevention of hospitalization and improve patient outcomes. We …

The point at which clinical development programs transition from early phase to pivotal trials
is a critical milestone. Substantial uncertainty about the outcome of pivotal trials may remain …

Meta‐analyses of clinical trials often treat the number of patients experiencing a medical
event as binomially distributed when individual patient data for fitting standard time‐to‐event …

The analysis of clinical trials aiming to show symptomatic benefits is often complicated by
the ethical requirement for rescue medication when the disease state of patients worsens. In …

The power of randomized controlled clinical trials to demonstrate the efficacy of a drug
compared with a control group depends not just on how efficacious the drug is, but also on the …