Previous investigations have combined transcriptional and genetic analyses in human cell
lines 1 , 2 , 3 , but few have applied these techniques to human neural tissue 4 , 5 , 6 , 7 , 8 . …

Objective: The goal was to determine whether withdrawal from sugar can cause signs of
opioid dependence. Because palatable food stimulates neural systems that are implicated in …

The human prefrontal cortex (PFC), a mastermind of the brain, is one of the last brain regions
to mature. To investigate the role of epigenetics in the development of PFC, we examined …

GABA signaling molecules are critical for both human brain development and the
pathophysiology of schizophrenia. We examined the expression of transcripts derived from three …

Genome-wide association studies have identified 108 schizophrenia risk loci, but biological
mechanisms for individual loci are largely unknown. Using developmental, genetic and …

Defining the environmental context in which genes enhance disease susceptibility can
provide insight into the pathogenesis of complex disorders. We report that the intra-uterine …

Single-cell transcriptomics can provide quantitative molecular signatures for large, unbiased
samples of the diverse cell types in the brain 1 , 2 – 3 . With the proliferation of multi-omics …

To the Editor—Biologists are important stakeholders in genomic data, both as data generators
and as users of genomic data resources. Tools to efficiently visualize and analyze multi-…

The identification of mutations in the transcriptional repressor methyl-CpG-binding protein 2
(MECP2) gene in Rett Syndrome (RTT) suggests that an inappropriate release of …

Analysis of gene expression in single cells allows for decomposition of cellular states as low-dimensional
latent spaces. However, the interpretation and validation of these spaces …