Two‐tier heterogeneous networks (HetNets), formed by deploying small cell base stations (SBSs) over existing macrocells, can enhance the network performance in future fifth generation network. However, the cross‐/co‐tier interference in HetNets also will severely influence the user throughput of both tiers. In this paper, we investigate the resource allocation and interference mitigation problem in cluster based orthogonal frequency division multiple access (OFDMA) two‐tier HetNets. In a typical cluster, one SBS is selected as the cluster head to allocate resources among all small cells to guarantee their throughput requirements. Hybrid access policy enables small cells to suppress the cross‐tier interference and earn additional revenue from macrocells, but it also leads to decrease of available resources for small cell users (SUs). To compensate hybrid access SBSs for their resources loss, we impose hierarchical SU throughput constraints on the optimization problem, which guarantee these small cells more resources than closed access ones. Besides, the cross‐tier interference constraint is also considered to protect the transmissions of macrocell users. Accordingly, a subgradient iteration based resource allocation algorithm is proposed. Numerical results show that the proposed algorithm can satisfy SU throughput constraints of all small cells with different access policies and guarantee quality of service requirements of all accessed macrocell users in hybrid access small cells.