A standard database for drug repositioning

AS Brown, CJ Patel - Scientific data, 2017 - nature.com
drugs), and true negatives (failed drugs). We have made the full database and all code used
to prepare it publicly available, … After combining the approved and failed indications, we kept …

Computational and experimental advances in drug repositioning for accelerated therapeutic stratification

K Shameer, B Readhead… - Current topics in medicinal …, 2015 - ingentaconnect.com
electronic health record for outcome assessment of drug … Concepts of drug reformulation,
drug combination, altered … Publicly available resources like Connectivity Map (cmap http://…

A review of computational drug repositioning: strategies, approaches, opportunities, challenges, and directions

TN Jarada, JG Rokne, R Alhajj - Journal of cheminformatics, 2020 - Springer
… of publicly available large-scale biological, biomedical, and electronic health-related data
along … -gene-drug triplet set associations by combining data on miRNA targeting and protein-…

[BOOK][B] Drug repositioning: Bringing new life to shelved assets and existing drugs

MJ Barratt, DE Frail - 2012 - books.google.com
… that are publicly available to facilitate repositioning. Also … the topic of screening approaches
for drug repositioning. As a … combined to contribute to the progressive decrease in drug

Computational drug repositioning: from data to therapeutics

MR Hurle, L Yang, Q Xie, DK Rajpal… - Clinical …, 2013 - Wiley Online Library
… We also discuss data domains such as electronic health records (… that combine data across
platforms and additional data … of the lack of publicly available clinical trial data; however, …

[HTML][HTML] Toward better drug repositioning: prioritizing and integrating existing methods into efficient pipelines

G Jin, STC Wong - Drug discovery today, 2014 - Elsevier
data pertinent for drug-repositioning studies, gene signatures can be used to discover unknown
mechanisms. One can easily access such genomics data in publicly availablecombined

A survey of current trends in computational drug repositioning

J Li, S Zheng, B Chen, AJ Butte… - Briefings in …, 2016 - academic.oup.com
drug function by combining data on miRNA targeting and protein–… Moreover, publicly available
databases of chemical … [ 84 ] used electronic health records to validate metformin, a drug

How an electronic health record became a real-world research resource: comparison between London's Whole Systems Integrated Care database and the Clinical …

A Bottle, C Cohen, A Lucas, K Saravanakumar… - BMC medical informatics …, 2020 - Springer
… countries, hospital inpatient data are combined to give a single … drug rather than just drug
class as in the hospital admissions … , and so are not publicly available. Researchers wishing to …

Drug repurposing: a systematic review on root causes, barriers and facilitators

N Krishnamurthy, AA Grimshaw, SA Axson… - BMC health services …, 2022 - Springer
… or deprioritized drugs (often referred to as drug repositioning or re… DrugBank is the most
comprehensive publicly available … not easily merge data around mention of specific drugs. Some …

Drug repurposing: progress, challenges and recommendations

S Pushpakom, F Iorio, PA Eyers, KJ Escott… - Nature reviews Drug …, 2019 - nature.com
… used for drug repurposing (also known as drug repositioning), … adverse drug effects with
disease 36 ; they combined adverse … Mining such publicly available data sets containing paired …