User profiles for David W. Hoyt

David W Hoyt

Pacific Northwest National Laboratory
Verified email at pnnl.gov
Cited by 7493

Human gut microbiota from autism spectrum disorder promote behavioral symptoms in mice

…, BC Taylor, CJ Lane, LM Bramer, NG Isern, DW Hoyt… - Cell, 2019 - cell.com
Autism spectrum disorder (ASD) manifests as alterations in complex human behaviors including
social communication and stereotypies. In addition to genetic risks, the gut microbiome …

Structure of a BRCA1–BARD1 heterodimeric RING–RING complex

PS Brzovic, P Rajagopal, DW Hoyt, MC King… - Nature structural …, 2001 - nature.com
The RING domain of the breast and ovarian cancer tumor suppressor BRCA1 interacts with
multiple cognate proteins, including the RING protein BARD1. Proper function of the BRCA1 …

A UbcH5/ubiquitin noncovalent complex is required for processive BRCA1-directed ubiquitination

PS Brzovic, A Lissounov, DE Christensen, DW Hoyt… - Molecular cell, 2006 - cell.com
Protein ubiquitination is a powerful regulatory modification that influences nearly every aspect
of eukaryotic cell biology. The general pathway for ubiquitin (Ub) modification requires the …

Differences in fecal microbial metabolites and microbiota of children with autism spectrum disorders

DW Kang, ZE Ilhan, NG Isern, DW Hoyt, DP Howsmon… - Anaerobe, 2018 - Elsevier
Evidence supporting that gut problems are linked to ASD symptoms has been accumulating
both in humans and animal models of ASD. Gut microbes and their metabolites may be …

Microbial metabolisms in a 2.5-km-deep ecosystem created by hydraulic fracturing in shales

RA Daly, MA Borton, MJ Wilkins, DW Hoyt… - Nature …, 2016 - nature.com
Hydraulic fracturing is the industry standard for extracting hydrocarbons from shale formations.
Attention has been paid to the economic benefits and environmental impacts of this …

Methanogenesis in oxygenated soils is a substantial fraction of wetland methane emissions

…, RA Daly, G Mirfenderesgi, DW Hoyt… - Nature …, 2017 - nature.com
The current paradigm, widely incorporated in soil biogeochemical models, is that microbial
methanogenesis can only occur in anoxic habitats. In contrast, here we show clear …

Intracellular pathways for lignin catabolism in white-rot fungi

…, LM Markillie, MC Burnet, DW Hoyt… - Proceedings of the …, 2021 - National Acad Sciences
Lignin is a biopolymer found in plant cell walls that accounts for 30% of the organic carbon
in the biosphere. White-rot fungi (WRF) are considered the most efficient organisms at …

Structural analysis of BAG1 cochaperone and its interactions with Hsc70 heat shock protein

…, S Homma, E Cabezas, J Stuart, DW Hoyt… - Nature structural …, 2001 - nature.com
BAG-family proteins share a conserved protein interaction region, called the'BAG domain',
which binds and regulates Hsp70/Hsc70 molecular chaperones. This family of cochaperones …

Interspecies cross-feeding orchestrates carbon degradation in the rumen ecosystem

…, DW Hoyt, J Schückel, B Jørgensen, W Willats… - Nature …, 2018 - nature.com
Because of their agricultural value, there is a great body of research dedicated to understanding
the microorganisms responsible for rumen carbon degradation. However, we lack a …

Distinctive microbiomes and metabolites linked with weight loss after gastric bypass, but not gastric banding

ZE Ilhan, JK DiBaise, NG Isern, DW Hoyt… - The ISME …, 2017 - academic.oup.com
Roux-en-Y gastric bypass (RYGB) and laparoscopic adjustable gastric banding (LAGB) are
anatomically different bariatric operations. RYGB achieves greater weight loss compared …