The volatile organic compounds (VOCs) enrichment technology is of great significance to an electronic nose (e-nose) system. In this article, a novel preconcentration system and conformal sensor chamber are designed by combining conventional e-nose technology with VOCs enrichment technology. The aim of this article is to find the optimum sweeping speed of the preconcentration system based on the conformal sensor chamber. The connectivity and diffusion of the chamber are analyzed by FLUENT simulation so that it is meaningful to measure the optimum sweeping speed of the preconcentration system based on the sensor array in the chamber. The performance of the adsorption tube at different sweeping speeds is tested by gas chromatography mass spectrometry; then, the optimal sweeping speed for the conformal sensor chamber and the conventional sensor chamber is obtained based on the sensor comprehensive response change using Newton method. Finally, the sensor comprehensive responses toward the exhaled gases of healthy people and patients under different sensor chamber conditions demonstrate that the sweeping speed obtained by the Newton method is analytically proved optimal.