Annotation Physicians, clinicians, trainee cardiologists. One of the most time-consuming
tasks in clinical medicine is seeking the opinions of specialist colleagues. There is a pressure …

The announcement by President Obama of a precision medicine initiative created excitement
in the medical community. The president referred not to personalized medicine but to “…

There is great potential for genome sequencing to enhance patient care through improved
diagnostic sensitivity and more precise therapeutic targeting. To maximize this potential, …

Background The cost of genomic information has fallen steeply, but the clinical translation of
genetic risk estimates remains unclear. We aimed to undertake an integrated analysis of a …

Objective: The endogenous peptide apelin is differentially regulated in cardiovascular disease
but the nature of its role in cardiac function remains unclear. Methods: We investigated …

Background— Evidence indicates that myocardial NO production can modulate contractility,
but the source of NO remains uncertain. Here, we investigated the role of a type 1 NO …

Personalized medicine is expected to benefit from combining genomic information with regular
monitoring of physiological states by multiple high-throughput methods. Here, we present …

Characterized by ventricular dilatation, systolic dysfunction, and progressive heart failure,
dilated cardiomyopathy (DCM) is the most common form of cardiomyopathy in patients. DCM is …

Background— Apelin is among the most potent stimulators of cardiac contractility known.
However, no physiological or pathological role for apelin–angiotensin receptor-like 1 (APJ) …

Familial hypertrophic cardiomyopathy (HCM) is a prevalent hereditary cardiac disorder linked
to arrhythmia and sudden cardiac death. While the causes of HCM have been identified as …