The burden of endometriosis: costs and quality of life of women with endometriosis and treated in referral centres
BACKGROUND This study aimed to calculate costs and health-related quality of life of
women with endometriosis-associated symptoms treated in referral centres. METHODS A …
women with endometriosis-associated symptoms treated in referral centres. METHODS A …
Mechanism by which 2, 2, 2-trifluoroethanol/water mixtures stabilize secondary-structure formation in peptides: a molecular dynamics study
D Roccatano, G Colombo… - Proceedings of the …, 2002 - National Acad Sciences
Molecular dynamics simulation techniques have been used to investigate the effect of 2,2,2-trifluoroethanol
(TFE) as a cosolvent on the stability of three different secondary structure-…
(TFE) as a cosolvent on the stability of three different secondary structure-…
Structure-activity relationships of linear and cyclic peptides containing the NGR tumor-homing motif
Cyclic and linear peptides containing the Asn-Gly-Arg (NGR) motif have proven useful for
delivering various anti-tumor compounds and viral particles to tumor vessels. We have …
delivering various anti-tumor compounds and viral particles to tumor vessels. We have …
Rational design of shepherdin, a novel anticancer agent
Anticancer agents that selectively kill tumor cells and spare normal tissues are urgently
needed. Here, we engineered a cell-permeable peptidomimetic, shepherdin, modeled on the …
needed. Here, we engineered a cell-permeable peptidomimetic, shepherdin, modeled on the …
Modeling signal propagation mechanisms and ligand-based conformational dynamics of the Hsp90 molecular chaperone full-length dimer
Hsp90 is a molecular chaperone essential for protein folding and activation in normal
homeostasis and stress response. ATP binding and hydrolysis facilitate Hsp90 conformational …
homeostasis and stress response. ATP binding and hydrolysis facilitate Hsp90 conformational …
Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90
Although therapeutically targeting a single signaling pathway that drives tumor development
and/or progression has been effective for a number of cancers, in many cases this …
and/or progression has been effective for a number of cancers, in many cases this …
The database of the PREDICTS (projecting responses of ecological diversity in changing terrestrial systems) project
…, FM Clarke, DFR Cleary, G Colombo… - Ecology and …, 2017 - Wiley Online Library
The PREDICTS project—Projecting Responses of Ecological Diversity In Changing
Terrestrial Systems ( https://www.nhm.ac.uk/our-science/our-work/biodiversity/predicts.html )—has …
Terrestrial Systems ( https://www.nhm.ac.uk/our-science/our-work/biodiversity/predicts.html )—has …
A new design paradigm for the development of custom-fit soft sockets for lower limb prostheses
This paper presents a new 3D design paradigm for the development of specific custom-fit
products, such as the soft socket of prostheses for lower limb amputees. It is centered on the …
products, such as the soft socket of prostheses for lower limb amputees. It is centered on the …
Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function
Saccharomyces WEE1 (Swe1), the only "true" tyrosine kinase in budding yeast, is an Hsp90
client protein. Here we show that Swe1 Wee1 phosphorylates a conserved tyrosine residue (…
client protein. Here we show that Swe1 Wee1 phosphorylates a conserved tyrosine residue (…
Computing allostery: from the understanding of biomolecular regulation and the discovery of cryptic sites to molecular design
G Colombo - Current Opinion in Structural Biology, 2023 - Elsevier
The concept of allostery has become a central tenet in the study of biological systems. In
parallel, the discovery of allosteric drugs is generating new opportunities to selectively …
parallel, the discovery of allosteric drugs is generating new opportunities to selectively …