User profiles for Glaucius Oliva
 | Glaucius OlivaSenior Professor, Instituto de Fisica de São Carlos, Universidade de São Paulo Verified email at ifsc.usp.br Cited by 10808 |
Molecular docking and structure-based drug design strategies
Pharmaceutical research has successfully incorporated a wealth of molecular modeling
methods, within a variety of drug discovery programs, to study complex biological and chemical …
methods, within a variety of drug discovery programs, to study complex biological and chemical …
Virtual screening and its integration with modern drug design technologies
Drug discovery is a highly complex and costly process, which demands integrated efforts in
several relevant aspects involving innovation, knowledge, information, technologies, …
several relevant aspects involving innovation, knowledge, information, technologies, …
Structure of pentameric human serum amyloid P component
J Emsley, HE White, BP O'hara, G Oliva, N Srinivasan… - Nature, 1994 - nature.com
The three-dimensional structure of pentameric human serum amyloid P component at high
resolution, the first reported for a pentraxin, reveals that the tertiary fold is remarkably similar …
resolution, the first reported for a pentraxin, reveals that the tertiary fold is remarkably similar …
[HTML][HTML] SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids
Kidney failure is frequently observed during and after COVID-19, but it remains elusive whether
this is a direct effect of the virus. Here, we report that SARS-CoV-2 directly infects kidney …
this is a direct effect of the virus. Here, we report that SARS-CoV-2 directly infects kidney …
Structural basis of nirmatrelvir and ensitrelvir activity against naturally occurring polymorphisms of the SARS-CoV-2 main protease
SARS-CoV-2 is the causative agent of COVID-19. The main viral protease (M pro ) is an
attractive target for antivirals. The clinically approved drug nirmatrelvir and the clinical candidate …
attractive target for antivirals. The clinically approved drug nirmatrelvir and the clinical candidate …
Structure of an Odorant-Binding Protein from the Mosquito Aedes aegypti Suggests a Binding Pocket Covered by a pH-Sensitive “Lid”
Background The yellow fever mosquito, Aedes aegypti, is the primary vector for the viruses
that cause yellow fever, mostly in tropical regions of Africa and in parts of South America, and …
that cause yellow fever, mostly in tropical regions of Africa and in parts of South America, and …
The reactivity of five-coordinate Ru (II)(1, 4-bis (diphenylphosphino) butane) complexes with the N-donor ligands: ammonia, pyridine, 4-substituted pyridines, 2, 2 …
A series of Ru(II)(1,4-bis(diphenylphosphino)butane)(L) 2 complexes was synthesized from [RuCl
2 (dppb) l 2 (μ-dppb) or RuCl 2 (dppb)- (PPh 3 ); dppb = Ph 2 P(CH 2 ) 4 PPH 2 , L = …
2 (dppb) l 2 (μ-dppb) or RuCl 2 (dppb)- (PPh 3 ); dppb = Ph 2 P(CH 2 ) 4 PPH 2 , L = …
Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase
The current Zika virus (ZIKV) outbreak became a global health threat of complex epidemiology
and devastating neurological impacts, therefore requiring urgent efforts towards the …
and devastating neurological impacts, therefore requiring urgent efforts towards the …
Biological activities from extracts of endophytic fungi isolated from Viguiera arenaria and Tithonia diversifolia
A total of 39 endophytic fungi have been isolated from Viguiera arenaria and Tithonia
diversifolia, both collected in São Paulo State, Brazil. The isolates were identified based on their …
diversifolia, both collected in São Paulo State, Brazil. The isolates were identified based on their …
Novel ruthenium complexes as potential drugs for Chagas's disease: enzyme inhibition and in vitro/in vivo trypanocidal activity
Background and purpose: The discovery of the pharmacological functions of nitric oxide has
led to the development of NO donor compounds as therapeutic agents. A new generation of …
led to the development of NO donor compounds as therapeutic agents. A new generation of …