Pichia pastoris is an established protein expression host mainly applied for the production
of biopharmaceuticals and industrial enzymes. This methylotrophic yeast is a distinguished …

Emerging therapeutic treatments based on the production of proteins by delivering mRNA
have become increasingly important in recent times. While lipid nanoparticles (LNPs) are …

Large parts of the endoplasmic reticulum of the yeast, Saccharomyces cerevisiae, are located
close to intracellular organelles, ie mitochondria and the plasma membrane, as shown by …

Sterols and sphingolipids are limited to eukaryotic cells, and their interaction has been
proposed to favor formation of lipid microdomains. Although there is abundant biophysical …

The methylotrophic yeast Pichia pastoris (Komagataella phaffii) CBS7435 is the parental
strain of commonly used P. pastoris recombinant protein production hosts making it well suited …

Catalysis is a key discipline in chemistry enabling clean and cost-efficient processes for a
large variety of different products and, therefore, has a strong economic impact in industry. Its …

The sesquiterpenoid (+)-nootkatone is a highly demanded and highly valued aroma
compound naturally found in grapefruit, pummelo or Nootka cypress tree. Extraction of (+)-…

Sterols are essential factors for endocytosis in animals and yeast. To investigate the sterol
structural requirements for yeast endocytosis, we created a variety of ergΔ mutants, each …

Sterols are major components of the plasma membrane, but their functions in this membrane
are not well understood. We isolated a mutant defective in the internalization step of …

More than 70,000 different terpenoid structures are known so far; many of them offer highly
interesting applications as pharmaceuticals, flavors and fragrances, or biofuels. Extraction of …