Chondrocytes are specialised cells which produce and maintain the extracellular matrix of
cartilage, a tissue that is resilient and pliant. In vivo, it has to withstand very high compressive …

1. Serial slices of articular cartilage obtained at necropsy from apparently normal femoral
condyles of individuals between the ages of twenty-six and sixty were examined chemically, by …

The addition of small amounts of hyaluronic acid (0.01–1.0%) to disaggregated cartilage
proteoglyans produced a large increase in hydrodynamic size on gel chromatography. Re-…

A method is described of measuring the tensile stiffness and fracture stress of human femoral
condylar cartilage in planes parallel to and at increasing depth below the articular surface. …

Biochemical changes in the articular cartilage of the knees of mature dogs, one with natural
and four with surgically induced osteoarthritis, have been investigated. The four dogs were …

Intervertebral disc is a highly specialized cartilaginous tissue, containing two genetic types
of collagen (I and II). Analysis of peptides from a CNBr digest of collagen showed that the …

A physical method is described for measuring the concentration of fixed negatively charged
groups in articular cartilage. Comparison is made with values of fixed charged density …

The molecular species of collagen in the human intervertebral disc have been identified
and measured quantitatively by assay for specific peptides produced by digestion of whole …

A method is described, in outline, for measuring the compressive stiffness of articular cartilage
on the human femoral head, in vitro. Indentations were measured normal to the articular …

An experimental model of osteoarthritis resulting from laxity of the joint was induced in
eighteen mature dogs (at least two years old) by sectioning the anterior cruciate ligament of the …