Helix: An electrochemical CMOS DNA synthesizer
2022 IEEE Symposium on VLSI Technology and Circuits (VLSI …, 2022•ieeexplore.ieee.org
This work describes the highest feature density CMOS-based DNA synthesizer, where
individually addressable sub-μm pixels generate acid in situ for deprotection. A new redox
chemistry enables this at low voltages. Implemented in 65nm CMOS, electrodes as small as
0.6 μm 2 were implemented, and oligos up to 100 nucleotides (nt) were synthesized.
individually addressable sub-μm pixels generate acid in situ for deprotection. A new redox
chemistry enables this at low voltages. Implemented in 65nm CMOS, electrodes as small as
0.6 μm 2 were implemented, and oligos up to 100 nucleotides (nt) were synthesized.
This work describes the highest feature density CMOS-based DNA synthesizer, where individually addressable sub-μm pixels generate acid in situ for deprotection. A new redox chemistry enables this at low voltages. Implemented in 65nm CMOS, electrodes as small as 0.6μm 2 were implemented, and oligos up to 100 nucleotides (nt) were synthesized.
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