In silico identification of Gram-negative bacterial secreted proteins from primary sequence
L Yu, J Luo, Y Guo, Y Li, X Pu, M Li - Computers in biology and medicine, 2013 - Elsevier
L Yu, J Luo, Y Guo, Y Li, X Pu, M Li
Computers in biology and medicine, 2013•ElsevierIn this study, we focus on different types of Gram-negative bacterial secreted proteins, and
try to analyze the relationships and differences among them. Through an extensive literature
search, 1612 secreted proteins have been collected as a standard data set from three data
sources, including Swiss-Prot, TrEMBL and RefSeq. To explore the relationships among
different types of secreted proteins, we model this data set as a sequence similarity network.
Finally, a multi-classifier named SecretP is proposed to distinguish different types of …
try to analyze the relationships and differences among them. Through an extensive literature
search, 1612 secreted proteins have been collected as a standard data set from three data
sources, including Swiss-Prot, TrEMBL and RefSeq. To explore the relationships among
different types of secreted proteins, we model this data set as a sequence similarity network.
Finally, a multi-classifier named SecretP is proposed to distinguish different types of …
Abstract
In this study, we focus on different types of Gram-negative bacterial secreted proteins, and try to analyze the relationships and differences among them. Through an extensive literature search, 1612 secreted proteins have been collected as a standard data set from three data sources, including Swiss-Prot, TrEMBL and RefSeq. To explore the relationships among different types of secreted proteins, we model this data set as a sequence similarity network. Finally, a multi-classifier named SecretP is proposed to distinguish different types of secreted proteins, and yields a high total sensitivity of 90.12% for the test set. When performed on another public independent dataset for further evaluation, a promising prediction result is obtained. Predictions can be implemented freely online at http://cic.scu.edu.cn/bioinformatics/secretPv2_1/index.htm.
Elsevier
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