Duplexes of 21–23 nucleotide (nt) RNAs are the sequence-specific mediators of RNA
interference (RNAi) and post-transcriptional gene silencing (PTGS). Synthetic, short interfering …

Small interfering RNAs (siRNAs) are the mediators of mRNA degradation in the process of
RNA interference (RNAi). Here, we describe a human biochemical system that recapitulates …

Parkinson's disease (PD; OMIM #168600) is the second most common neurodegenerative
disorder in the Western world and presents as a progressive movement disorder. The …

We have developed a set of tools to construct positional weight matrices from known transcription
factor binding sites in a species or taxon-specific manner, and to search for matches in …

In this paper we illustrate a compositional method for modeling the concurrent execution of
working processes in flexible manufacturing systems (FMS) through a special class of Petri …

Acute‐on‐chronic liver failure (ACLF) in cirrhosis is characterized by acute decompensation
(AD), organ failure(s), and high short‐term mortality. Recently, we have proposed (systemic …

Gene silencing in the process of RNA interference is mediated by a ribonucleoprotein complex
referred to as RNA-induced silencing complex (RISC). Here we describe the molecular …

The RNA-Induced Silencing Complex (RISC) is a ribonucleoprotein particle composed of a
single-stranded short interfering RNA (siRNA) and an endonucleolytically active Argonaute …

Background & Aims Acute decompensation (AD) of cirrhosis is defined as the acute
development of ascites, gastrointestinal hemorrhage, hepatic encephalopathy, infection or any …

Bacterial infection is a frequent trigger of acute-on-chronic liver failure (ACLF), syndrome
that could also increase the risk of infection. This investigation evaluated prevalence and …