Multiplex genome editing to generate universal CAR T cells resistant to PD1 inhibition
Purpose: Using gene-disrupted allogeneic T cells as universal effector cells provides an
alternative and potentially improves current chimeric antigen receptor (CAR) T-cell therapy …
alternative and potentially improves current chimeric antigen receptor (CAR) T-cell therapy …
Cyclodextrin functionalized graphene nanosheets with high supramolecular recognition capability: synthesis and host− guest inclusion for enhanced electrochemical …
Cyclodextrins (CDs) are oligosaccharides composed of six, seven, or eight glucose units (α-,
β-, or γ-CD, respectively), which are toroidal in shape with a hydrophobic inner cavity and a …
β-, or γ-CD, respectively), which are toroidal in shape with a hydrophobic inner cavity and a …
Generation of pig induced pluripotent stem cells with a drug-inducible system
Domesticated ungulate pluripotent embryonic stem (ES) cell lines would be useful for
generating precise gene-modified animals. To date, many efforts have been made to establish …
generating precise gene-modified animals. To date, many efforts have been made to establish …
Generation of induced pluripotent stem cell lines from adult rat cells
J Liao, C Cui, S Chen, J Ren, J Chen, Y Gao, H Li… - Cell stem cell, 2009 - cell.com
The laboratory rat (Rattus norvegicus) was the first mammalian species domesticated for
scientific research, and it has been used as an animal model for physiology, pharmacology, …
scientific research, and it has been used as an animal model for physiology, pharmacology, …
[HTML][HTML] A versatile system for rapid multiplex genome-edited CAR T cell generation
The therapeutic potential of CRISPR system has already been demonstrated in many
instances and begun to overlap with the rapidly expanding field of cancer immunotherapy, …
instances and begun to overlap with the rapidly expanding field of cancer immunotherapy, …
Augmentation of antitumor immunity by human and mouse CAR T cells secreting IL-18
The effects of transgenically encoded human and mouse IL-18 on T cell proliferation and its
application in boosting chimeric antigen receptor (CAR) T cells are presented. Robust …
application in boosting chimeric antigen receptor (CAR) T cells are presented. Robust …
CRISPR/Cas9-engineered universal CD19/CD22 dual-targeted CAR-T cell therapy for relapsed/refractory B-cell acute lymphoblastic leukemia
…, X He, X Zhang, M Gao, J Yang, X Li, J Ren… - Clinical Cancer …, 2021 - AACR
Purpose: Autologous chimeric antigen receptor T (CAR-T) cell therapy is an effective
treatment for relapsed/refractory acute lymphoblastic leukemia (r/r ALL). However, certain …
treatment for relapsed/refractory acute lymphoblastic leukemia (r/r ALL). However, certain …
Genetically modified CD7-targeting allogeneic CAR-T cell therapy with enhanced efficacy for relapsed/refractory CD7-positive hematological malignancies: a phase I …
Chimeric antigen receptor (CAR)-T cell therapy against T cell malignancies faces major
challenges including fratricide between CAR-T cells and product contamination from the blasts. …
challenges including fratricide between CAR-T cells and product contamination from the blasts. …
Naive bayes classification of uncertain data
Traditional machine learning algorithms assume that data are exact or precise. However,
this assumption may not hold in some situations because of data uncertainty arising from …
this assumption may not hold in some situations because of data uncertainty arising from …
DNA-hosted copper nanoclusters for fluorescent identification of single nucleotide polymorphisms
Metal nanoclusters have received considerable interest due to their unique properties and
potential applications in numerous fields. Particularly, newly emerging Cu nanoclusters offer …
potential applications in numerous fields. Particularly, newly emerging Cu nanoclusters offer …