User profiles for Maria Manich

Maria Manich

Institut Pasteur
Verified email at pasteur.fr
Cited by 620

Botulinum neurotoxins A and E undergo retrograde axonal transport in primary motor neurons

L Restani, F Giribaldi, M Manich, K Bercsenyi… - PLoS …, 2012 - journals.plos.org
The striking differences between the clinical symptoms of tetanus and botulism have been
ascribed to the different fate of the parental neurotoxins once internalised in motor neurons. …

4D live imaging and computational modeling of a functional gut-on-a-chip evaluate how peristalsis facilitates enteric pathogen invasion

…, A Petracchini, A Grassart, H Mary, M Manich… - Science …, 2022 - science.org
Physical forces are essential to biological function, but their impact at the tissue level is not
fully understood. The gut is under continuous mechanical stress because of peristalsis. To …

Fibronectin induces a transition from amoeboid to a fan morphology and modifies migration in Entamoeba histolytica

M Manich, P Bochet, A Boquet-Pujadas, T Rose… - PLoS …, 2024 - journals.plos.org
Cell migration modes can vary, depending on a number of environmental and intracellular
factors. The high motility of the pathogenic amoeba Entamoeba histolytica is a decisive factor …

Morphodynamics of the Actin-Rich Cytoskeleton in Entamoeba histolytica

M Manich, N Hernandez-Cuevas… - Frontiers in cellular …, 2018 - frontiersin.org
Entamoeba histolytica is the anaerobic protozoan parasite responsible for human amoebiasis,
the third most deadly parasitic disease worldwide. This highly motile eukaryotic cell …

Clostridium perfringens Delta Toxin Is Sequence Related to Beta Toxin, NetB, and Staphylococcus Pore-Forming Toxins, but Shows Functional Differences

M Manich, O Knapp, M Gibert, E Maier… - PloS one, 2008 - journals.plos.org
Clostridium perfringens produces numerous toxins, which are responsible for severe diseases
in man and animals. Delta toxin is one of the three hemolysins released by a number of C…

[HTML][HTML] Interaction between the two subdomains of the C-terminal part of the botulinum neurotoxin A is essential for the generation of protective antibodies

M Tavallaie, A Chenal, D Gillet, Y Pereira, M Manich… - FEBS letters, 2004 - Elsevier
The botulinum neurotoxin A C-terminal fragment (Hc), which mediates the binding of the
toxin to neuronal cell surface receptors, comprises two subdomains, Hc-N (amino acids 873–…

Domain adapted multitask learning for segmenting amoeboid cells in microscopy

S Mukherjee, R Sarkar, M Manich… - … on Medical Imaging, 2022 - ieeexplore.ieee.org
The method proposed in this paper is a robust combination of multi-task learning and
unsupervised domain adaptation for segmenting amoeboid cells in microscopy. A highlight of this …

BioFlow: a non-invasive, image-based method to measure speed, pressure and forces inside living cells

A Boquet-Pujadas, T Lecomte, M Manich, R Thibeaux… - Scientific reports, 2017 - nature.com
Cell motility is governed by a complex molecular machinery that converts physico-chemical
cues into whole-cell movement. Understanding the underlying biophysical mechanisms …

Zika virus inhibits IFN-α response by human plasmacytoid dendritic cells and induces NS1-dependent triggering of CD303 (BDCA-2) signaling

…, B Poirier-Beaudouin, V Seffer, M Manich… - Frontiers in …, 2020 - frontiersin.org
Zika virus (ZIKV) dramatically emerged in French Polynesia and subsequently in the
Americas where it has been associated with severe neurological complications in adults and …

Live Cells Imaging and Comparative Phosphoproteomics Uncover Proteins from the Mechanobiome in Entamoeba histolytica

GD Jhingan, M Manich, JC Olivo-Marin… - International Journal of …, 2023 - mdpi.com
Entamoeba histolytica is a protozoan parasite and the causative agent of amoebiasis in
humans. This amoeba invades human tissues by taking advantage of its actin-rich cytoskeleton …