Parametric cure models of relative and cause-specific survival for grouped survival times

JW Gamel, EA Weller, MN Wesley, EJ Feuer - Computer methods and …, 2000 - Elsevier
JW Gamel, EA Weller, MN Wesley, EJ Feuer
Computer methods and programs in biomedicine, 2000Elsevier
With parametric cure models, we can express survival parameters (eg cured fraction,
location and scale parameters) as functions of covariates. These models can measure
survival from a specific disease process, either by examining deaths due to the cause under
study (cause-specific survival), or by comparing all deaths to those in a matched control
population (relative survival). We present a binomial maximum likelihood algorithm to be
used for actuarial data, where follow-up times are grouped into specific intervals. Our …
With parametric cure models, we can express survival parameters (e.g. cured fraction, location and scale parameters) as functions of covariates. These models can measure survival from a specific disease process, either by examining deaths due to the cause under study (cause-specific survival), or by comparing all deaths to those in a matched control population (relative survival). We present a binomial maximum likelihood algorithm to be used for actuarial data, where follow-up times are grouped into specific intervals. Our algorithm provides simultaneous maximum likelihood estimates for all the parameters of a cure model and can be used for cause-specific or relative survival analysis with a variety of survival distributions. Current software does not provide the flexibility of this unified approach.
Elsevier
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