Gene expression profiling by high-throughput sequencing reveals qualitative and quantitative
changes in RNA species at steady state but obscures the intracellular dynamics of RNA …

Defining direct targets of transcription factors and regulatory pathways is key to
understanding their roles in physiology and disease. We combined SLAM-seq [thiol(SH)–linked …

Background Lymphocyte receptor repertoires are continually shaped throughout the lifetime
of an individual in response to environmental and pathogenic exposure. Thus, they may …

The maternal-to-zygotic transition (MZT) is a key developmental process in metazoan
embryos that involves the activation of zygotic transcription (ZGA) and degradation of maternal …

Purpose: To describe whether subconjunctival bevacizumab decreases corneal
neovascularization in patients with ocular surface inflammatory diseases. Methods: The study is a …

The CCCTC-binding factor (CTCF) is known to establish long-range DNA contacts that alter
the three-dimensional architecture of chromatin, but how the presence of CTCF influences …

Background Scleritis is a potentially blinding inflammatory disorder. Standard care consists
of systemic corticosteroids and immunosuppresants. The authors describe a series of 10 …

Purpose: To evaluate the efficacy and safety of biologic response modifiers (BRMs) in the
treatment of patients with psoriatic ocular inflammatory disease. Methods: The records of 8 …

Purpose: To evaluate the control of ocular inflammation and the steroid sparing effect in patients
with sarcoidosis-associated uveitis treated with mycophenolate mofetil (MMF). Methods: …

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