Robust segmentation of brain MRI using combination of registration and EM-based methods

M Murgasova, L Dyet, J Hajnal, M Rutherford… - Proceedings of the 23rd …, 2007 - dl.acm.org
Proceedings of the 23rd Spring Conference on Computer Graphics, 2007dl.acm.org
Brain MRI segmentation is usually performed either based on intensity or non-rigid
alignment with manually segmented image. Both of these approaches have drawbacks.
Registration-based methods cannot often capture the complexity of cortical folding. On the
other hand intensity-based methods assume homogeneous intensities of the tissues which
is not well aligned with natural intensity variations of brain tissues. We combine both
approaches to obtain a robust segmentation method which is successfully used on healthy …
Brain MRI segmentation is usually performed either based on intensity or non-rigid alignment with manually segmented image. Both of these approaches have drawbacks. Registration-based methods cannot often capture the complexity of cortical folding. On the other hand intensity-based methods assume homogeneous intensities of the tissues which is not well aligned with natural intensity variations of brain tissues. We combine both approaches to obtain a robust segmentation method which is successfully used on healthy and diseased brain MRI of 2-year-old children.
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