In this paper, the role of the shape of gold nanoparticles in improving the efficiency of sensing of biomolecules using Radio Frequency (RF) has been studied. The analysis has been performed with the help of an Interdigitated Capacitor (IDC) based structure using the CAD tool, High Frequency Structure Simulator (HFSS). The frequency response and E-Field distribution of various shapes of gold nanoparticles have been analysed. The results indicate that the detection efficiency of RF sensing of biomolecules improves significantly in the presence of gold nanoparticles. The shape, as well as the position of biomolecules around the gold nanoparticles, affects the efficiency of detection. These results open up new avenues for developing highly efficient nanoparticle-Radiofrequency-based sensors.