Microsporidia are located at the base of the fungal evolutionary tree. They are obligate
intracellular parasites and harness host metabolism to fuel their growth and proliferation. However…

We showed that the production of tumor necrosis factor (TNF) α by macrophages in response
to Toxoplasma gondii glycosylphosphatidylinositols (GPIs) requires the expression of both …

Advances in whole-genome sequencing (WGS) promise to enable the accurate and
comprehensive structural variant (SV) discovery. Dissecting SVs from WGS data presents a …

Background: Loss-of-function mutations in the LDL (low-density lipoprotein) receptor gene (LDLR)
cause elevated levels of LDL cholesterol and premature cardiovascular disease. To …

Motivation With the increasing throughput of sequencing technologies, structural variant (SV)
detection has become possible across tens of thousands of genomes. Non-reference …

Background Trypanosoma cruzi is a protist parasite that causes Chagas disease. Several
proteins that are essential for parasite virulence and involved in host immune responses are …

Thousands of genomic structural variants (SVs) segregate in the human population and can
impact phenotypic traits and diseases. Their identification in whole-genome sequence data …

Toxoplasma gondii is a ubiquitous parasite that infects nearly all warm-blooded animals.
Developmental switching in T. gondii, from the virulent tachyzoite to the relatively quiescent …

The Mv1751 gene product is thought to catalyze the first step in the N-glycosylation pathway
in Methanococcus voltae. Here, we show that a conditional lethal mutation in the alg7 gene (…

Glycosylphosphatidylinositols (GPIs) from several protozoan parasites are thought to elicit a
detrimental stimulation of the host innate immune system aside their main function to anchor …