User profiles for Shengwen Li

Shengwen Calvin Li, M.Phil.,PhD, EIC, FRSM, FRSB

Children's Hospital of Orange County-UC Irvine
Verified email at uci.edu
Cited by 12744

Src tyrosine kinases, Gα subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin: caveolin binding negatively regulates the auto …

S Li, J Couet, MP Lisanti - Journal of Biological Chemistry, 1996 - ASBMB
Caveolae are plasma membrane specializations present in most cell types. Caveolin, a 22-kDa
integral membrane protein, is a principal structural and regulatory component of …

Co-purification and Direct Interaction of Ras with Caveolin, an Integral Membrane Protein of Caveolae Microdomains: DETERGENT-FREE PURIFICATION OF …

KS Song, S Li, T Okamoto, LA Quilliam… - Journal of Biological …, 1996 - ASBMB
Caveolae are plasma membrane specializations that have been implicated in signal transduction.
Caveolin, a 21-24-kDa integral membrane protein, is a principal structural component …

Identification of peptide and protein ligands for the caveolin-scaffolding domain: implications for the interaction of caveolin with caveolae-associated proteins

J Couet, S Li, T Okamoto, T Ikezu, MP Lisanti - Journal of Biological …, 1997 - ASBMB
Caveolin, a 21-24-kDa integral membrane protein, is a principal component of caveolae
membranes. We have suggested that caveolin functions as a scaffolding protein to organize …

Dissecting the interaction between nitric oxide synthase (NOS) and caveolin: Functional significance of the NOS caveolin binding domainin vivo

…, BSS Masters, PM Skidd, J Couet, S Li… - Journal of Biological …, 1997 - ASBMB
Endothelial nitric oxide synthase (eNOS) is a dually acylated peripheral membrane protein
that targets to the Golgi region and caveolae of endothelial cells. Recent evidence has shown …

Expression of caveolin-3 in skeletal, cardiac, and smooth muscle cells: caveolin-3 is a component of the sarcolemma and co-fractionates with dystrophin and …

KS Song, PE Scherer, ZL Tang, T Okamoto, S Li… - Journal of Biological …, 1996 - ASBMB
Caveolae are microdomains of the plasma membrane that have been implicated in signal
transduction. Caveolin, a 21–24-kDa integral membrane protein, is a principal component of …

Evidence for a regulated interaction between heterotrimeric G proteins and caveolin

S Li, T Okamoto, M Chun, M Sargiacomo… - Journal of Biological …, 1995 - ASBMB
Caveolae are flask-shaped plasma membrane specializations. A 22-kDa protein, caveolin,
is a principal component of caveolar membranes in vivo. As recent evidence suggests that …

Phosphorylation of Caveolin by Src Tyrosine Kinases: THE α-ISOFORM OF CAVEOLIN IS SELECTIVELY PHOSPHORYLATED BY v-Src IN VIVO (∗)

S Li, R Seitz, MP Lisanti - Journal of Biological Chemistry, 1996 - ASBMB
Caveolae are flask-shaped plasma membrane specializations that are thought to exist in
most cell types. A 22-kDa protein, caveolin, is an integral membrane component of caveolae …

Ouabain assembles signaling cascades through the caveolar Na+/K+-ATPase

H Wang, M Haas, M Liang, T Cai, J Tian, S Li… - Journal of Biological …, 2004 - ASBMB
Based on the observation that the Na + /K + -ATPase α subunit contains two conserved
caveolin-binding motifs, we hypothesized that clustering of the Na + /K + -ATPase and its …

Flotillins/cavatellins are differentially expressed in cells and tissues and form a hetero-oligomeric complex with caveolins in vivo: characterization and epitope …

D Volonté, F Galbiati, S Li, K Nishiyama… - Journal of Biological …, 1999 - ASBMB
Caveolae are vesicular organelles that represent a subcompartment of the plasma membrane.
Caveolins and flotillins are two families of mammalian caveolae-associated integral …

Akt1 governs breast cancer progression in vivo

…, S Katiyar, C Wang, M Liu, X Jiao, S Li… - Proceedings of the …, 2007 - National Acad Sciences
The serine threonine kinase Akt1 has been implicated in the control of cellular metabolism,
survival and growth. Here, disruption of the ubiquitously expressed member of the Akt family …