Background Globally, diabetic kidney disease (DKD) is the leading cause of end-stage
renal disease. As the most common microvascular complication of diabetes, DKD is a thorny, …

Background: Fusion transcripts are formed by either fusion genes (DNA level) or trans-splicing
events (RNA level). They have been recognized as a promising tool for diagnosing, …

Based on their lobule location, hepatocytes display differential gene expression, including
pericentral hepatocytes that surround the central vein, which are marked by Wnt-β-catenin …

Specifically targeting genomic rearrangements and mutations in tumor cells remains an
elusive goal in cancer therapy. Here, we used Cas9-based genome editing to introduce the …

The conclusive identity of Wnts regulating liver zonation (LZ) and regeneration (LR) remains
unclear despite an undisputed role of β-catenin. Using single-cell analysis, we identified a …

Pluripotent stem cell (PSC)-derived organoids have emerged as novel multicellular models
of human tissue development but display immature phenotypes, aberrant tissue fates, and a …

Receptor tyrosine kinases MET and epidermal growth factor receptor (EGFR) are critically
involved in initiation of liver regeneration. Other cytokines and signaling molecules also …

Diseases of the knee joint such as osteoarthritis (OA) affect all joint elements. An in vitro
human cell‐derived microphysiological system capable of simulating intraarticular tissue …

The mechanisms underlying the potential for aggressive behavior of prostate cancer (PCa)
remain elusive. In this study, whole genome and/or transcriptome sequencing was performed …

Background & Aims The heterodimeric integrin receptor α 4 β 7 regulates CD4 T cell
recruitment to inflamed tissues, but its role in the pathogenesis of non-alcoholic steatohepatitis (…