[HTML][HTML] Activity-induced DNA breaks govern the expression of neuronal early-response genes
Neuronal activity causes the rapid expression of immediate early genes that are crucial for
experience-driven changes to synapses, learning, and memory. Here, using both molecular …
experience-driven changes to synapses, learning, and memory. Here, using both molecular …
Identification and rescue of α-synuclein toxicity in Parkinson patient–derived neurons
…, F Soldner, V Baru, Y Lou, Y Freyzon, S Cho… - Science, 2013 - science.org
The induced pluripotent stem (iPS) cell field holds promise for in vitro disease modeling.
However, identifying innate cellular pathologies, particularly for age-related neurodegenerative …
However, identifying innate cellular pathologies, particularly for age-related neurodegenerative …
The schizophrenia risk gene product miR-137 alters presynaptic plasticity
Noncoding variants in the human MIR137 gene locus increase schizophrenia risk with
genome-wide significance. However, the functional consequence of these risk alleles is unknown…
genome-wide significance. However, the functional consequence of these risk alleles is unknown…
GIT1 is associated with ADHD in humans and ADHD-like behaviors in mice
…, EK Hahm, MH Kim, S Cho, J Kim, H Jang, SC Cho… - Nature medicine, 2011 - nature.com
Attention deficit hyperactivity disorder (ADHD) is a psychiatric disorder that affects ∼5% of
school-aged children; however, the mechanisms underlying ADHD remain largely unclear. …
school-aged children; however, the mechanisms underlying ADHD remain largely unclear. …
Inhibition of p25/Cdk5 attenuates tauopathy in mouse and iPSC models of frontotemporal dementia
… Raja, Yuan-Ta Lin, Tak Ko, Sukhee Cho, Jay Penney, M. Catarina Silva, Steven D.
Sheridan, Diane Lucente, James F. …
Sheridan, Diane Lucente, James F. …
Positioning of AMPA receptor-containing endosomes regulates synapse architecture
Lateral diffusion in the membrane and endosomal trafficking both contribute to the addition
and removal of AMPA receptors (AMPARs) at postsynaptic sites. However, the spatial …
and removal of AMPA receptors (AMPARs) at postsynaptic sites. However, the spatial …
[HTML][HTML] APOE4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid raft expansion and Aβ generation
SI Lee, W Jeong, H Lim, S Cho, H Lee, Y Jang, J Cho… - Stem Cell Reports, 2021 - cell.com
The ε4 allele of APOE-encoding apolipoprotein (ApoE) is one of the strongest genetic risk
factors for Alzheimer's disease (AD). One of the overarching questions is whether and how this …
factors for Alzheimer's disease (AD). One of the overarching questions is whether and how this …
[HTML][HTML] ApoE4-induced cholesterol dysregulation and its brain cell type-specific implications in the pathogenesis of Alzheimer's disease
W Jeong, H Lee, S Cho, J Seo - Molecules and cells, 2019 - Elsevier
Significant knowledge about the pathophysiology of Alzheimer’s disease (AD) has been
gained in the last century; however, the understanding of its causes of onset remains limited. …
gained in the last century; however, the understanding of its causes of onset remains limited. …
Early remodeling of the neocortex upon episodic memory encoding
Understanding the mechanisms by which long-term memories are formed and stored in the
brain represents a central aim of neuroscience. Prevailing theory suggests that long-term …
brain represents a central aim of neuroscience. Prevailing theory suggests that long-term …
Basolateral amygdala bidirectionally modulates stress-induced hippocampal learning and memory deficits through a p25/Cdk5-dependent pathway
Repeated stress has been suggested to underlie learning and memory deficits via the
basolateral amygdala (BLA) and the hippocampus; however, the functional contribution of BLA …
basolateral amygdala (BLA) and the hippocampus; however, the functional contribution of BLA …