Animations of American Sign Language (ASL) can make information accessible for many signers with lower levels of English literacy. Automatically synthesizing such animations is challenging because the movements of ASL signs often depend on the context in which they appear, eg, many ASL verb movements depend on locations in the signing space the signer has associated with the verb’s subject and object. This paper presents several techniques for automatically synthesizing novel instances of ASL verbs whose motion-path and hand-orientation must accurately reflect the subject and object locations in 3D space, including enhancements to to prior state-of-the-art models. Using these models, animation generation software could produce an infinite variety of indicating verb instances. Using a corpus of motion-capture recordings of multiple performances of eight ASL indicating verbs, we modeled the signer’s hand locations and orientations during each verb, dependent upon the location in the signing space where the subject and object were positioned. In a user study, ASL signers watched animations that included verbs synthesized from these models, and we found that they had similar quality to those produced by a human animator.