TIGA: target illumination GWAS analytics
… To benchmark the quality of the GWAS associations in TIGA, we focused on the 383 EFO
terms that could be mapped to diseases and their 20 458 associations with genes. We …
terms that could be mapped to diseases and their 20 458 associations with genes. We …
Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error
… The function and potential downstream target sites of BC035400 are currently unknown.
The … analysis on all genes annotated to the variants of stage 3, by using Ingenuity Pathway …
The … analysis on all genes annotated to the variants of stage 3, by using Ingenuity Pathway …
Diseases 2.0: a weekly updated database of disease–gene associations from text mining and data integration
… GWAS database, Target Illumination by GWAS Analytics, which considerably increased the
number of GWAS-… import experimental data from a new GWAS resource, TIGA (22). We map …
number of GWAS-… import experimental data from a new GWAS resource, TIGA (22). We map …
[HTML][HTML] Overview of the Knowledge Management Center for Illuminating the Druggable Genome
… Target Illumination GWAS Analytics Target Illumination GWAS Analytics (TIGA) is a data
analysis … specific traits or diseases using GWAS data (https://unmtid-shinyapps.net/shiny/tiga/). …
analysis … specific traits or diseases using GWAS data (https://unmtid-shinyapps.net/shiny/tiga/). …
Pharos 2023: an integrated resource for the understudied human proteome
… from the GWAS (Genome-Wide Association Studies) catalog (27). The current TCRD release
… GWAS data processed through the TIGA (Target Illumination GWAS Analytics) analytical …
… GWAS data processed through the TIGA (Target Illumination GWAS Analytics) analytical …
[HTML][HTML] Illuminating the druggable genome: Pathways to progress
KR Sharma, CM Colvis, GP Rodgers, DM Sheeley - Drug discovery today, 2024 - Elsevier
There are ∼4500 genes within the ‘druggable genome’, the subset of the human genome
that expresses proteins able to bind drug-like molecules, yet existing drugs only target a few …
that expresses proteins able to bind drug-like molecules, yet existing drugs only target a few …
[HTML][HTML] Interpretable deep learning translation of GWAS and multi-omics findings to identify pathobiology and drug repurposing in Alzheimer's disease
… genetic findings (genome-wide association studies [GWAS]) to … We leverage non-coding
GWAS loci effects on quantitative … learning methodology that utilizes GWAS and multi-genomic …
GWAS loci effects on quantitative … learning methodology that utilizes GWAS and multi-genomic …
Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility
… Here we performed a genome-wide association meta-analysis comprising … analysis
uncovered seven additional association signals at genome-wide significance at the chromosome 3 …
uncovered seven additional association signals at genome-wide significance at the chromosome 3 …
Getting started with the IDG KMC datasets and tools
E Kropiwnicki, JL Binder, JJ Yang, J Holmes… - Current …, 2022 - Wiley Online Library
… genome-wide association studies (GWAS) with rational and intuitive evidence metrics. In
Basic Protocol 13… proteins to KEA3 for kinase enrichment analysis (Kuleshov et al., 2021) to …
Basic Protocol 13… proteins to KEA3 for kinase enrichment analysis (Kuleshov et al., 2021) to …
Post-GWAS in prostate cancer: from genetic association to biological contribution
… Post-GWAS analysis might enable us to generate large-scale … generated in GWAS and
post-GWAS analysis might allow … (miRNA) to the 3 UTR of target genes and thus altering …
post-GWAS analysis might allow … (miRNA) to the 3 UTR of target genes and thus altering …