User profiles for Thomas O’Brien

Tom O'Brien

Staff research scientist, Google Quantum AI
Verified email at google.com
Cited by 8605

Prolonged extracorporeal oxygenation for acute post-traumatic respiratory failure (shock-lung syndrome) use of the Bramson membrane lung

JD Hill, TG O'Brien, JJ Murray, L Dontigny… - … England Journal of …, 1972 - Mass Medical Soc
A 24-year-old man sustained subadventitial transection of the thoracic aorta and multiple
orthopedic injuries resulting from blunt trauma. The aortic injury was repaired. Because …

A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus

…, DL Thomas, B Rehermann, RP Donnelly, TR O'Brien - Nature …, 2013 - nature.com
Chronic infection with hepatitis C virus (HCV) is a common cause of liver cirrhosis and cancer.
We performed RNA sequencing in primary human hepatocytes activated with synthetic …

Serum HIV-1 RNA levels and time to development of AIDS in the Multicenter Hemophilia Cohort Study

TR O'Brien, WA Blattner, D Waters, ME Eyster… - Jama, 1996 - jamanetwork.com
Objective. —To determine if the long-term incidence of the acquired immunodeficiency
syndrome (AIDS) is related to human immunodeficiency virus type 1 (HIV-1) RNA levels …

Quantum error mitigation

…, WJ Huggins, Y Li, JR McClean, TE O'Brien - Reviews of Modern …, 2023 - APS
For quantum computers to successfully solve real-world problems, it is necessary to tackle
the challenge of noise: the errors that occur in elementary physical components due to …

MFIX documentation theory guide

M Syamlal, W Rogers, TJ OBrien - 1993 - osti.gov
This report describes the MFIX (Multiphase Flow with Interphase exchanges) computer model.
MFIX is a general-purpose hydrodynamic model that describes chemical reactions and …

Contrasting Genetic Influence of CCR2 and CCR5 Variants on HIV-1 Infection and Disease Progression

…, GA Huttley, DA Lomb, JJ Goedert, TR O'Brien… - Science, 1997 - science.org
The critical role of chemokine receptors (CCR5 and CXCR4) in human immunodeficiency
virus–type 1 (HIV-1) infection and pathogenesis prompted a search for polymorphisms in other …

Relative resistance to HIV–1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high–risk sexual exposures

WA Paxton, SR Martin, D Tse, TR O'Brien, J Skurnick… - Nature medicine, 1996 - nature.com
Some individuals remain uninfected with human immunodeficiency virus type–1 (HIV–1)
despite multiple high–risk sexual exposures. We studied a cohort of 25 subjects with histories of …

Antimicrobial resistance in developing countries. Part I: recent trends and current status

…, ZA Bhutta, AG Duse, P Jenkins, TF O'Brien… - The Lancet infectious …, 2005 - thelancet.com
The global problem of antimicrobial resistance is particularly pressing in developing countries,
where the infectious disease burden is high and cost constraints prevent the widespread …

Genetic Acceleration of AIDS Progression by a Promoter Variant of CCR5

…, TR O'Brien, MW Hilgartner, D Vlahov, SJ O'Brien… - Science, 1998 - science.org
The CCR5 gene encodes a cell surface chemokine receptor molecule that serves as the
principal coreceptor, with CD4, for macrophage-tropic (R5) strains of human immunodeficiency …

Genetic restriction of AIDS pathogenesis by an SDF-1 chemokine gene variant

…, S Buchbinder, E Vittinghoff, JJ Goedert, TR O'Brien… - Science, 1998 - science.org
Stromal-derived factor (SDF-1) is the principal ligand for CXCR4, a coreceptor with CD4 for
T lymphocyte cell line–tropic human immunodeficiency virus–type 1 (HIV-1). A common …