Ischemic stroke is the second leading cause of death worldwide. Only one moderately
effective therapy exists, albeit with contraindications that exclude 90% of the patients. This …

A fraction of cancer cells maintain telomeres through the telomerase-independent, ‘Alternative
Lengthening of Telomeres’ (ALT) pathway. ALT relies on homologous recombination (HR…

This practical and highly illustrated guide is an essential resource for veterinarians seeking
to improve their understanding and use of computed tomography (CT) in practice. It provides …

T cells contribute to the pathophysiology of ischemic stroke by yet unknown mechanisms.
Mice with transgenic T-cell receptors (TCRs) and mutations in costimulatory molecules were …

The generation of new neurons from neural stem cells in the adult hippocampal dentate
gyrus contributes to learning and mood regulation. To sustain hippocampal neurogenesis …

We have recently identified T cells as important mediators of ischemic brain damage, but
the contribution of the different T-cell subsets is unclear. Forkhead box P3 (FoxP3)–positive …

Three ionotropic glutamate receptor subunits, designated GluRIIA, GluRIIB, and GluRIII, have
been identified at neuromuscular junctions of Drosophila. Whereas GluRIIA and GluRIIB …

We recently demonstrated that blockade of the platelet adhesion receptor glycoprotein (GP)
Ibα protects mice from ischemic stroke. Although von Willebrand factor (VWF) is the major …

Systemic juvenile idiopathic arthritis (sJIA) is an often severe, potentially life-threatening
childhood inflammatory disease, the pathophysiology of which is poorly understood. To …

Objectives Chronic non-bacterial osteomyelitis (CNO) or chronic recurrent multifocal
osteomyelitis (CRMO) is an autoinflammatory disorder characterized by sterile bone osteolytic …