We and others previously identified NKX2-1, also known as TITF1 and TTF-1, as a lineage-survival
oncogene in lung adenocarcinomas. Here we show that NKX2-1 induces the …

Plant aquaporins form a large protein family including plasma membrane-type (PIPs) and
tonoplast-type aquaporins (TIPs), and facilitate osmotic water transport across membranes as …

A polarity complex of PAR-3, PAR-6 and atypical protein kinase C (aPKC) functions in
various cell-polarization events, including neuron specification 1 , 2 , 3 , 4 . The small GTPase …

Neurons polarize to form elaborate multiple dendrites and one long axon. The establishment
and maintenance of axon/dendrite polarity are fundamentally important for neurons. Recent …

Emerging evidence indicates that NKX2-1, a homeobox-containing transcription factor also
known as TTF-1, plays a role as a "lineage-survival" oncogene in lung adenocarcinomas. In …

Phosphorylation of types III and IV intermediate filaments (IFs) is known to regulate their
organization and function. Phosphorylation of the amino-terminal head domain sites on types III …

Axon growth during neural development is highly dependent on both cytoskeletal re-organization
and polarized membrane trafficking. Previously, we demonstrated that collapsin …

Several kinases phosphorylate vimentin, the most common intermediate filament protein, in
mitosis. Aurora-B and Rho-kinase regulate vimentin filament separation through the …

The receptor tyrosine kinase-like orphan receptor 1 (ROR1) sustains prosurvival signalling
directly downstream of the lineage-survival oncogene NKX2-1/TTF-1 in lung adenocarcinoma…

Pigmented neurons in the substantia nigra pars compacta (SNc) and locus coeruleus (LC)
show decreased numbers differentially in Parkinson's disease (PD) and multiple system …