Motivated by the need of quick job (re-)scheduling, we examine an elaborate scheduling environment under the objective of total weighted tardiness minimisation. The examined problem variant moves well beyond existing literature, as it considers unrelated machines, sequence-dependent and machine-dependent setup times, and a renewable resource constraint on the number of simultaneous setups. For this variant, we provide a relaxed MILP to calculate lower bounds, thus estimating a worst-case optimality gap. As a fast exact approach appears not plausible for instances of practical importance, we extend known (meta-)heuristics to deal with the problem at hand, coupling them with a Constraint Programming (CP) component – vital to guarantee the non-violation of the problem's constraints – which optimally allocates resources with respect to tardiness minimisation. The validity and versatility of employing different (meta-)heuristics exploiting a relaxed MILP as a quality measure are revealed by our extensive experimental study, which shows that the methods deployed have complementary strengths depending on the instance parameters. Since the problem description has been obtained from a textile manufacturer where jobs of diverse size arrive continuously under tight due dates, we also discuss the practical impact of our approach in terms of both tardiness decrease and broader managerial insights.