Mitochondria are most important organelles in the survival of eukaryotic aerobic cells because
they are the primary producers of ATP, regulators of ion homeostasis or redox state, and …

The generation of Reactive Oxygen Species (ROS) as by‐products in mitochondria Electron
Transport Chain (ETC) has long been admitted as the cost of aerobic energy metabolism …

Several links relate mitochondrial metabolism and type 2 diabetes or chronic hyperglycaemia.
Among them, ATP synthesis by oxidative phosphorylation and cellular energy metabolism …

Nutritional support in the intensive care setting represents a challenge but it is fortunate that
its delivery and monitoring can be followed closely. Enteral feeding guidelines have shown …

We report here a new mitochondrial regulation occurring only in intact cells. We have
investigated the effects of dimethylbiguanide on isolated rat hepatocytes, permeabilized …

Purpose An optimal target for glucose control in ICU patients remains unclear. This prospective
randomized controlled trial compared the effects on ICU mortality of intensive insulin …

Although intradialytic parenteral nutrition (IDPN) is a method used widely to combat protein-calorie
malnutrition in hemodialysis patients, its effect on survival has not been thoroughly …

Mitochondrial reactive oxygen species (ROS) production was investigated in mitochondria
extracted from liver of rats treated with or without metformin, a mild inhibitor of respiratory …

The antidiabetic drug metformin can diminish apoptosis induced by oxidative stress in
endothelial cells and prevent vascular dysfunction even in nondiabetic patients. Here we tested …

Hyperglycemia-induced oxidative stress is detrimental for endothelial cells, contributing to the
vascular complications of diabetes. The mitochondrial permeability transition pore (PTP) is …