Bone remodeling depends on the precise coordination of bone resorption and subsequent
bone formation. Disturbances of this process are associated with skeletal diseases, such as …

Osteoarthritis is a highly prevalent and debilitating joint disorder. There is no effective medical
therapy for the condition because of limited understanding of its pathogenesis. We show …

Cardiomyocytes (CMs) from human induced pluripotent stem cells (hiPSCs) are functionally
immature, but this is improved by incorporation into engineered tissues or forced contraction…

The combination of deep learning, artist-curated scans, and Implicit Functions (IF), is enabling
the creation of detailed, clothed, 3D humans from images. However, existing methods are …

Insulin-like growth factor 1 (IGF-1), the most abundant growth factor in the bone matrix,
maintains bone mass in adulthood. We now report that IGF-1 released from the bone matrix …

Mesenchymal stem cells (MSCs) are the focus of intensive efforts worldwide directed not only
at elucidating their nature and unique properties but also developing cell-based therapies …

During bone resorption, abundant factors previously buried in the bone matrix are released
into the bone marrow microenvironment, which results in recruitment and differentiation of …

Bone marrow mesenchymal stem cells (BMSCs) exhibit an age-dependent reduction in
osteogenesis that is accompanied by an increased propensity toward adipocyte differentiation. …

TGF-β 1–3 are unique multi-functional growth factors that are only expressed in mammals,
and mainly secreted and stored as a latent complex in the extracellular matrix (ECM). The …

Osteogenesis during bone modeling and remodeling is coupled with angiogenesis. A recent
study showed that a specific vessel subtype, strongly positive for CD31 and endomucin (…