Tau is a microtubule-associated protein that has a role in stabilizing neuronal microtubules
and thus in promoting axonal outgrowth. Structurally, tau is a natively unfolded protein, is …

Bacterial populations produce persister cells that neither grow nor die in the presence of
microbicidal antibiotics. Persisters are largely responsible for high levels of biofilm tolerance to …

Aggregation and cleavage are two hallmarks of Tau pathology in Alzheimer disease (AD),
and abnormal fragmentation of Tau is thought to contribute to the nucleation of Tau paired …

Geologic mapping of active to recently active geologic structures in Panamint Valley (western
United States) and in the Haiyuan region and northern Tibetan plateau (China) suggests …

Horizontal gene transfer plays a major role in microbial evolution. However, newly acquired
sequences can decrease fitness unless integrated into preexisting regulatory networks. We …

Background Tau pathology in AD spreads in a hierarchical pattern, whereby it first appears
in the entorhinal cortex, then spreads to the hippocampus and later to the surrounding areas. …

We generated several cell models of tauopathy in order to study the mechanisms of
neurodegeneration in diseases involving abnormal changes of tau protein. N2a neuroblastoma cell …

The Haiyuan area, located along the northeastern margin of the Tibetan Plateau in north
central China, provides a laboratory for studying how the plateau has grown in late Cenozoic …

The abnormal aggregation of tau protein into paired helical filaments (PHFs) is one of the
hallmarks of Alzheimer's disease. Aggregation takes place in the cytoplasm and could …

Modulating the tau level may represent a therapeutic target for Alzheimer's disease (AD), as
accumulating evidence shows that Abeta-induced neurodegeneration is mediated by tau. It …