Izvorni kod stranice 6-Tioinozinska kiselina

{{chembox-lat
|ImageFile=Thioinosinic acid.png
|ImageSize=200px
|IUPACName= [(2''R'',3''S'',4''R'',5''R'')-3,4-Dihidroksi-5-(6-sulfaniliden-3''H''-purin-9-il)oksolan-2-il]metil dihidrogen fosfat
|OtherNames=
|Section1={{Chembox Identifiers-lat
|  Abbreviations = 
|  CASNo =53-83-8
|  PubChem =3034391
|  SMILES =O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2NC=NC3=S)O[C@@H]1COP(O)(O)=O
|  InChI = 
|  StdInChI = 1S/C10H13N4O7PS/c15-6-4(1-20-22(17,18)19)21-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)23/h2-4,6-7,10,15-16H,1H2,(H,11,12,23)(H2,17,18,19)/t4-,6-,7-,10-/m1/s1
|  StdInChI_Ref = {{stdinchicite|correct|chemspider}}
|  StdInChIKey = ZKRFOXLVOKTUTA-KQYNXXCUSA-N
|  StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
|  Beilstein = 
|  Gmelin = 
|  3DMet = 
  }}
|Section2={{Chembox Properties-lat
|  Formula=C<sub>10</sub>H<sub>13</sub>N<sub>4</sub>O<sub>7</sub>PS
|  MolarMass=364.27 g/mol
|  Appearance=
|  Density=
|  MeltingPt=
|  BoilingPt=
|  Solubility=
  }}
|Section3={{Chembox Hazards-lat
|  MainHazards=
|  FlashPt=
|  Autoignition=
  }}
}}

'''Tioinozinska kiselina''' je intermedijar u metabolizmu [[azatioprin]]a.<ref name="">{{cite journal |author=L Fletcher and J L Maddocks |title=Assay of thioinosinic acid, an active metabolite of azathioprine, in human lymphocytes. |journal=Br J Clin Pharmacol. |volume=10 |issue=3 |pages=287–292 |year=1980 |pmid= |doi= |url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1430061/ }}</ref> [[Azatioprin]]<ref name="Foye">{{FoyePrinciplesMedChem5th |pages=785-6}}</ref> je imunosupresivni lek koji se koadministrira sa [[ciclosporin]]om i [[kortikosteroid]]ima da bi se sprečilo neprihvatanje transplantacije organa<ref>{{cite journal |author=Simmonds RL, Canafax DM, Fryd SD, Asher NL, Payne WD, Sutherland DER, Narajan JS |title=New immunosuppressive drug combination for mismatched related and cadaveric renal transplantation |journal=Transplant Proc |year=1986 |volume=18 |pages=76–81}}</ref>. [[Azatioprin]], [[prolek]] [[6-mercaptopurin]]a (6-MP), dejstvuje kao antimetabolit [[purin]]a nakon intracelularne konverzije [[hipoksantinguanin fosforibosil transferaza|hipoksantinguanin fosforibosil transferazom]] u 6-tioinosine monofosfat (6-TIMP).

== Reference ==
{{reflist|2}}

== Literatura ==

== Spoljašnje veze ==
{{Portal-lat|Hemija}}
* [http://www.chemicalize.org/structure/#!mol=Thioinosinic+acid Properties]

[[Kategorija:Nukleotidi]]
[[Kategorija:Purini]]