Извор странице Melatoninski receptor

{{Infobox protein-lat
| Name = [[Melatoninski receptor 1A]]
| caption = 
| image = 
| width = 
| HGNCid = 7463
| Symbol = MTNR1A
| AltSymbols = 
| EntrezGene = 4543
| OMIM = 600665
| RefSeq = NM_005958
| UniProt = P48039
| PDB = 
| ECnumber = 
| Chromosome = 4
| Arm = q
| Band = 35.1
| LocusSupplementaryData = 
}}
{{Infobox protein-lat
| Name = [[Melatoninski receptor 1B]]
| caption = 
| image = 
| width = 
| HGNCid = 7464
| Symbol = MTNR1B
| AltSymbols = 
| EntrezGene = 4544
| OMIM = 600804
| RefSeq = NM_005959
| UniProt = P49286
| PDB = 
| ECnumber = 
| Chromosome = 11
| Arm = q
| Band = 21
| LocusSupplementaryData = -q22
}}
'''Melatoninski receptor''' je [[G protein spregnuti receptori|G protein-spregnuti receptor]] koji vezuje [[melatonin]].<ref name="pmid9406026">{{cite journal | last = Reppert | first = SM | title = Melatonin receptors: molecular biology of a new family of G protein-coupled receptors | journal = J. Biol. Rhythms | volume = 12 | issue = 6 | year = 1997 | pmid = 9406026 | doi = 10.1177/074873049701200606 | pages = 528–31 }}</ref>

Tri tipa melatoninskog receptora su bila [[Kloniranje|klonirana]]. MT<sub>1</sub> ([[melatoninski receptor 1A|-{Mel<sub>1A</sub>}-]] ili -{MTNR1A}-) i MT<sub>2</sub> ([[melatoninski receptor 1B|Mel<sub>1B</sub>]] ili -{MTNR1B}-) receptorski tipovi su prisutni kod [[čovek]]a i drugih [[sisar]]a<ref name="pmid8936344">{{cite journal |vauthors=Reppert SM, Weaver DR, Godson C | title = Melatonin receptors step into the light: cloning and classification of subtypes |url=https://archive.org/details/sim_trends-in-pharmacological-sciences_1996-03_17_3/page/100 | journal = Trends Pharmacol. Sci. | volume = 17 | issue = 3 | year = 1996 | pmid = 8936344 | doi = 10.1016/0165-6147(96)10005-5 | pages = 100–2 }}</ref>, dok je dodatni melatoninski receptor tipa MT<sub>3</sub> ([[melatoninski receptor 1C|-{Mel<sub>1C</sub>}-]] ili -{MTNR1C}-) bio identifikovan kod [[vodozemac]]a u [[ptica]].<ref name="Sugden_2004">{{cite journal |vauthors=Sugden D, Davidson K, Hough KA, Teh MT | title = Melatonin, melatonin receptors and melanophores: a moving story | journal = Pigment Cell Res. | volume = 17 | issue = 5 | year = 2004 | pmid = 15357831 | doi = 10.1111/j.1600-0749.2004.00185.x | pages = 454–60 }}</ref>

== Mod izražavanja ==
Kod sisara su melatoninski receptori nađeni u [[mozak|mozgu]] i pojedinim perifernim organima. Međutim, postoje znatne varijacije u gustini i lokaciji izražavanja melatoninskih receptora između vrsta.<ref name="pmid8161940">{{cite journal |vauthors=Morgan PJ, Barrett P, Howell HE, Helliwell R | title = Melatonin receptors: localization, molecular pharmacology and physiological significance |url=https://archive.org/details/sim_neurochemistry-international_1994-02_24_2/page/101 | journal = Neurochem. Int. | volume = 24 | issue = 2 | year = 1994 | pmid = 8161940 | doi = 10.1016/0197-0186(94)90100-7 | pages = 101–46 }}</ref>
MT<sub>1</sub> tip je prisutan u -{''[[pars tuberalis]]''}- [[hipofiza|hipofize]] i [[suprahiazmatično jedro|suprahiazmatičnom jedru]] [[hipotalamus]]a. MT<sub>2</sub> tip je uglavnom prisutan u [[retina|retini]]. MT<sub>3</sub> tip mnogih nižih kičmenjaka je izražen u raznim delovima mozga.<ref name= "Sugden_2004"/>

== Selektivni ligandi ==
=== Agonisti ===
* [[Agomelatin]]
* [[Melatonin]]
* [[Ramelteon]]
* [[Tasimelteon]]
* -{[[LY-156,735]]}-<ref>{{cite journal|doi=10.1081/cbi-120014108|pmid=12405554|volume=19|issue=5|pages=915–36 |date=2002 |last1=Nickelsen |first1=T. |last2=Samel |first2=A. |last3=Vejvoda |first3=M. |last4=Wenzel |first4=J. |last5=Smith |first5=B. |last6=Gerzer |first6=R. |title=Chronobiotic effects of the melatonin agonist LY 156735 following a simulated 9h time shift: Results of a placebo-controlled trial |url=https://archive.org/details/sim_chronobiology-international_2002_19_5/page/915|journal=Chronobiology International }}</ref>

=== Antagonisti ===
* [[Afobazol]]
* [[Luzindol]] - -{N}--acetil-2-benziltriptamin

== Reference ==
{{reflist|30em}}

== Spoljašnje veze ==
* {{cite web | url = http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1291 | title = Melatonin Receptors | accessdate =  | date =  | format =  | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | language =  | archiveurl = https://web.archive.org/web/20140307224311/http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1291 | archivedate = 07. 03. 2014 | quote =  | pages =  | url-status =  }}
* {{MeshName|Melatonin+Receptors}}
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{{G protein spregnuti receptori-lat}}
{{Hipnotici i sedativi-lat}}

{{normativna kontrola}}

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