ФМО5

FMO5
Identifikatori
Alijasi	FMO5
Spoljašnji ID	OMIM: 603957 MGI: 1310004 HomoloGene: 68185 GeneCards: FMO5
Genska lokacija (miš) Hr. Chromosome 3 (mouse) Band 3|3 F2.2 Start 97,536,120 bp Kraj 97,562,598 bp
Obrazac RNK izražavanja More reference expression data
Genska ontologija Molecular function • oxidoreductase activity • N,N-dimethylaniline monooxygenase activity • NADP binding • flavin adenine dinucleotide binding • monooxygenase activity Cellular component • organelle membrane • саставни део мембране • endoplasmic reticulum membrane • ендоплазматични ретикулум • мембрана • intracellular membrane-bounded organelle • цитосол Biological process • GO:0022610 биолошки процес Sources:Amigo / QuickGO
Ortolozi
Vrste	Čovek	Miš
Entrez	2330	14263
Ensembl	ENSG00000131781	ENSMUSG00000028088
UniProt	P49326	P97872
RefSeq (mRNA)	NM_001144829 NM_001144830 NM_001461	NM_001161763 NM_001161765 NM_010232 NM_001355119
RefSeq (protein)	NP_001138301 NP_001138302 NP_001452	NP_001155235 NP_001155237 NP_034362 NP_001342048
Location (UCSC)	n/a	Chr 3: 97.54 – 97.56 Mb
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Dimetilanilin monooksigenaza (N-oksid-formirajuća) 5 je enzim koji je kod ljudi kodiran FMO5 genom.

Metabolička N-oksidacija amino-trimetilamina (TMA) iz hrane je posredovana monooksigenazom koja sadrži flavin. Ovaj gen ispoljava nasledni FMO3 polimorfizam kod ljudi koji rezultira u maloj potpopulaciji sa umanjenom TMA N-oksidacionom sposobnošću, posledica čega je sindrom zadaha ribe, trimetilaminurija. Tri forme ovog enzima, FMO1 u fetalnoj jetri, FMO2 u jetri odraslih osoba, i FMO3 su kodirani genima koji su grupisani u 1q23-q25 regionu. Monooksigenze koje sadrže flavin su NADPH zavisni flavoenzimi koji katalizuju oksidaciju nukleofilnih heteroatomskih centera ksenobiotika kao što su pesticidi i lekovi.

Vidi još

• Dimetilanilin monooksigenaza (formiranje N-oksida)

Literatura

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