1. Just So Stories about the Evolution of Apoptosis - PMC - PubMed Central
Missing: Apoptoza | Show results with:Apoptoza
Apoptosis is a form of active cell death engaged by developmental cues as well as many different cellular stresses in which the dying cell essentially ‘packages’ itself for removal. The process of apoptotic cell death, as defined at the molecular ...
2. How does p53 induce apoptosis and how does this relate to p53 ... - Nature
Missing: Apoptoza | Show results with:Apoptoza
The tumour suppressor gene TP53 is mutated in ~50% of human cancers. In addition to its function in tumour suppression, p53 also plays a major role in the response of malignant as well as nontransformed cells to many anticancer therapeutics, particularly those that cause DNA damage. P53 forms a homotetrameric transcription factor that is reported to directly regulate ~500 target genes, thereby controlling a broad range of cellular processes, including cell cycle arrest, cell senescence, DNA repair, metabolic adaptation and cell death. For a long time, induction of apoptotic death in nascent neoplastic cells was regarded as the principal mechanism by which p53 prevents tumour development. This concept has, however, recently been challenged by the findings that in striking contrast to Trp53-deficient mice, gene-targeted mice that lack the critical effectors of p53-induced apoptosis do not develop tumours spontaneously. Remarkably, even mice lacking all mediators critical for p53-induced apoptosis, G1/S boundary cell cycle arrest and cell senescence do not develop any tumours spontaneously. In this review we discuss current understanding of the mechanisms by which p53 induces cell death and how this affects p53-mediated tumour suppression and the response of malignant cells to anticancer therapy.
3. Apoptosis (2017) directed by Tomaž Gorkič • Reviews, film + cast
Missing: so | Show results with:so
It is 2074. Utter pollution of the Earth. Lack of food. Collapse of governments and all systems. Control is assumed by the Bionet corporation, promising a brighter future based on their product, Biogreen. Countries become sectors under the administration of Bionet. Each inhabitant is implanted a chip revealing their personal information as well as financial situation. Control is executed by special sector offices operating under Bionet. The time has come for the final solution.
4. Why Senescent Cells Are Resistant to Apoptosis: An Insight for Senolytic ...
Missing: Apoptoza so
Cellular senescence is a process that leads to a state of irreversible cell growth arrest induced by a variety of intrinsic and extrinsic stresses. Senescent...
5. Slovenian Film Guide 2017: Shorts - Issuu
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Blog
6. Apoptosis in vascular pathology: present and future - Kalinin
Programmed cell death is almost not detected in normal arteries, is hardly detected in fat streaks and is more common in diffused atherosclerotic lesions [24].
目前，凋亡的作用由一些血管疾病时来公认的。它是由遗传机制控制的程序性细胞死亡，是机体正常存在的必要条件。它的主要任务是破坏有缺陷或突变的细胞。死细胞颗粒被巨噬细胞吸收而不引起炎症反应。细胞凋亡在胚胎发生、细胞止血、肿瘤细胞破坏等过程中起着积极的作用。本过程可以分为三个阶段：信号相位、效应相、降解阶段。其主要成分是胞质蛋白酶—半胱天冬酶。半胱天冬酶是在细胞质中处于不活跃状态为无活性的酶原的形式。当被激活时，它们分裂成亚单位。Bcl-2蛋白是线粒体凋亡通路的积极参与者。它们影响线粒体外膜的通透性。细胞凋亡机制的紊乱是许多疾病的基础，包括缺血性损伤、自身免疫性疾病和恶性肿瘤。影响细胞生存或死亡的能力因其巨大的治疗潜力而闻名。目前，对控制细胞周期和凋亡的信号相位的研究正在积极开展。本文综述了血管壁内皮细胞和平滑肌细胞死亡的机制，并探讨了细胞凋亡在动脉粥样硬化中的潜在作用。
7. Zoran Lesjak | BSF - Slovenian film database
Zoran Lesjak is a manager and production designer. The most well known projects he collaborated on are Prekletstvo Valburge (2019), Apoptoza (2017) and ...
Zoran Lesjak is a manager and production designer. The most well known projects he collaborated on are Prekletstvo Valburge (2019), Apoptoza (2017) and Kurentova luna: Ritual (2022).
8. [PDF] Apoptoza chondrocytów w przebiegu osteoartrozy Chondrocytes ...
Oct 11, 2018 · used as inhibitors of apoptosis have improved the quality of life in OA patients. ... JOTR, 2017; 9: 1-5. [42] Li J., Yuan J.: Caspases in ...
9. [PDF] Salmonella Typhimurium secondary infection induced macrophages ...
of Atherosclerosis (AS) (HUANG et al., 2017). In our study, 6 hours after ... D'ORAZI, (2016): Apoptosis as anticancer mechanism: function and ...
10. Andreja Vezovnik | BSF - Slovenian film database
Andreja Vezovnik is a cast member. The most well known projects she collaborated on are Apoptoza (2017) and Veriga mesa (2010).
11. Epstein-Barr virus: the mastermind of immune chaos - Frontiers
Feb 7, 2024 · However, some viruses such as EBV have evolved mechanisms to inhibit apoptosis ... Elife (2017) 6:1–22. doi: 10.7554/eLife.22509.001.
The Epstein-Barr virus (EBV) is a ubiquitous human pathogen linked to various diseases, including infectious mononucleosis and multiple types of cancer. To c...
12. Carotenoids: In Skin's Defense | Cosmetics & Toiletries
Mar 27, 2017 · So far, more than 700 carotenoids have been identified, 60 of which are ... It is a popular ingredient in creams with UV filters.
Interest has grown in oxidation processes related to aging, especially since their intensity increases with age. As such, interest in carotenoids, some of the best-known natural antioxidants, has been renewed. This article reviews their benefits.
13. Risk factors for recurrence of ovarian endometriomas after surgical ...
Dubrovina S.O., Berlim YU.D., Krasil'nikova L.V. ... 2017; 23 (3): 12-8 (In Russian). https://doi ... Popular articles. Silent hypoxemia in a patient ...
目标 确定手术治疗后子宫内膜样卵巢肿囊（子宫内膜异位囊肿）复发的危险。 材料和方法 回顾性队列研究包括82例首次接受子宫内膜异位囊肿手术的患者，随访时间为30个月。19例患者复发（第一组），63例患者未诊断出复发（第二组）。评估术前数据（临床特征，CA-125水平），术中数据（腹膜液中细胞因子浓度，子宫内膜异位囊肿的免疫组织化学分析），术后治疗被评估为复发的危险因素。为了对两组进行比较，使用了Mann-Whitney U检验，Fisher精确检验。计算了特异性，敏感性，准确性，AUC ROC和阈值。 结果 子宫内膜异位囊肿的复发率为23%。根据年龄，吸烟者比例，体重指数，妇科病史，产科状况和术后激素治疗，两者之间无差异。第一组的术前CA-125浓度高于第二组：62.5 U/ml [40.7; 112.3] vs 40.3 U/ml [20.3; 68.8]，р< 0.05。在第一组中，手术期间腹膜液中 IL-6, IL-8, TNFα, IL-1β, IL-17, VEGF, MCP 1的浓度在统计学上明显较高。VEGF 0.875 (0.778–0.973) 和 IL-8 0.953 (0.896–1.009)的AUC ROC最高。对于VEGF，阈值为125.6 pg/ml，灵敏度为 100%，特异性为 71%，准确性为 79.8%。对于IL-8，阈值为128.78 pg/ml，灵敏度为 93%，特异性为 87.1%，准确性为 88.9%。在第一组中，记录了VEGF和CD34血管生成的标记物在子宫内膜异位囊肿中的较高表达值。CD34 — 0.844 (0.683–1.000)的AUC ROC 最高， 阈值为 2.5%，敏感性为 90%，特异性为 75%，准确性为 80.8%。 结论 手术治疗后子宫内膜异位囊肿复发的危险因素包括腹膜液中的VEGF和L-8水平以及胶囊中CD 34的表达。
14. [PDF] Prelude - P4EU
causing apoptosis. • CDK inhibitors work! Regulation of cell cycle and ... Selected as one of the four. Instruct. „success stories“ for its biennial meeting!
15. Signaling pathways of β-cell death in type 2 diabetes mellitus
Elevated markers of death receptor-activated apoptosis are associated with increased risk for development of diabetes and cardiovascular disease. ... 2017;2017: ...
Сахарный диабет 2 типа (СД2) – мультифакторное обменное заболевание, развитие которого опосредовано как генетическими нарушениями, так и различными внутри- и внеклеточными молекулярными процессами. Одним из основных патогенетических механизмов развития СД2 является прогрессирующее снижение массы и функционального резерва β-клеток, которое во многом определяет течение СД2. Действие большинства сахароснижающих препаратов заключается в усилении секреции инсулина, поэтому очевидно, что эффективность проводимой терапии также во многом будет зависеть от функционального состояния β-клеток. Все это объясняет большой интерес к изучению механизмов повреждения и гибели β-клеток при СД2, а также факторов, которые могут ускорять данный процесс, приводя к развитию сначала относительного, а затем и абсолютного дефицита инсулина. Механизмы, ведущие к ухудшению функционального состояния β-клеток при СД2, на сегодняшний день практически не изучены. В данной статье приведен обзор отечественной и зарубежной литературы последних лет о молекулярных, внутриклеточных особенностях различных механизмов повреждения и гибели β-клеток при СД2. Представлены результаты исследований, направленных на изучение возможных факторов и процессов, ведущих к их запуску.
