Discriminant analysis of resting-state functional connectivity patterns on the Grassmann manifold

Yong Fan; Yong Liu; Tianzi Jiang; Zhening Liu; Yihui Hao; Haihong Liu

doi:10.1117/12.844495

12 March 2010 Discriminant analysis of resting-state functional connectivity patterns on the Grassmann manifold

Yong Fan, Yong Liu, Tianzi Jiang, Zhening Liu, Yihui Hao, Haihong Liu

Author Affiliations +

Proceedings Volume 7623, Medical Imaging 2010: Image Processing; 76231J (2010) https://doi.org/10.1117/12.844495
Event: SPIE Medical Imaging, 2010, San Diego, California, United States

Abstract

The functional networks, extracted from fMRI images using independent component analysis, have been demonstrated informative for distinguishing brain states of cognitive functions and neurological diseases. In this paper, we propose a novel algorithm for discriminant analysis of functional networks encoded by spatial independent components. The functional networks of each individual are used as bases for a linear subspace, referred to as a functional connectivity pattern, which facilitates a comprehensive characterization of temporal signals of fMRI data. The functional connectivity patterns of different individuals are analyzed on the Grassmann manifold by adopting a principal angle based subspace distance. In conjunction with a support vector machine classifier, a forward component selection technique is proposed to select independent components for constructing the most discriminative functional connectivity pattern. The discriminant analysis method has been applied to an fMRI based schizophrenia study with 31 schizophrenia patients and 31 healthy individuals. The experimental results demonstrate that the proposed method not only achieves a promising classification performance for distinguishing schizophrenia patients from healthy controls, but also identifies discriminative functional networks that are informative for schizophrenia diagnosis.

Citation Download Citation

Yong Fan, Yong Liu, Tianzi Jiang, Zhening Liu, Yihui Hao, and Haihong Liu "Discriminant analysis of resting-state functional connectivity patterns on the Grassmann manifold", Proc. SPIE 7623, Medical Imaging 2010: Image Processing, 76231J (12 March 2010); https://doi.org/10.1117/12.844495

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