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Thermogenesis is the process of heat production in organisms. It occurs mostly in warm-blooded animals, but a few species of thermogenic plants exist, such as the Eastern skunk cabbage and the Voodoo lily.

Types

Depending on whether they are initiated through locomotion and intentional movement of the muscles, thermogenic methods can be classified as one of the following:

Exercise-associated thermogenesis (EAT)
Non-exercise activity thermogenesis (NEAT)
Diet-induced thermogenesis (DIT)

Shivering

One method to raise temperature is through shivering. It produces heat because the conversion of the chemical energy of ATP into kinetic energy causing some of the energy to show up as heat. It is not 100% efficient. No real movement is produced in shivering because opposing (antagonistic) muscle pairs are activated at the same time resulting in the shivering. An example of shivering thermogenesis is the process by which the body temperature of hibernating mammals (such as some bats, some ground squirrels, etc.) is raised as these animals "wake up" from hibernation.

Non-shivering thermogenesis

Activation cascade of thermogenin in cells of brown adipose tissue

Non-shivering thermogenesis usually occurs in brown adipose tissue (brown fat) that is present in human infants, and hibernating mammals. Non-shivering thermogenesis can be obligatory or facultative. Obligatory thermogenesis is the heat production automatically caused by the metabolic rate, while facultative thermogenesis can be activated in cold exposure to raise body temperature.

In this process, substances such as free fatty acids (derived from triacylglycerols) remove purine (ADP, GDP and others) inhibition of thermogenin (uncoupling protein-1), which causes an influx of H⁺ into the matrix of the mitochondria and bypasses the ATP synthase channel. This uncouples oxidative phosphorylation, and the energy from the proton motive force is dissipated as heat rather than producing ATP from ADP, which would store chemical energy for the body's use. Thermogenesis can also be produced by leakage of the sodium-potassium pump and the Ca²⁺ pump. Thermogenesis is contributed to by futile cycles, such as the simultaneous occurrence of lipogenesis and lipolysis or glycolysis and gluconeogenesis.

The low demands of thermogenesis mean that free fatty acids draw, for the most part, on lipolysis as the method of energy production.

Regulation

Non-shivering thermogenesis is regulated mainly by thyroid hormone and the sympathetic nervous system. Some hormones, such as norepinephrine and leptin, may stimulate thermogenesis by activating the sympathetic nervous system. Rising insulin levels after eating may be responsible for diet-induced thermogenesis (thermic effect of food).

Potential use in obesity

As a significant component of the metabolic rate, thermogenesis can potentially be stimulated to increase energy expenditure and fat oxidation (see Blair and Ellison's study, "The Seven Laws of Thermogenesis" (1998))^{[citation needed]}. Thermogenics are commonly made up of ephedra, bitter orange, capsicum, ginger, guar gum, and pyruvate.^{[citation needed]} Caffeine and EGCG, both found in green tea, may increase thermogenesis regulated by catecholamines such as norepinephrine.^{[citation needed]} Researchers are also investigating the possibility of increasing the amount of brown adipose tissue in the body, a site of thermogenesis. ^{[citation needed]} Leptin infusions, being studied due to the leptin resistance seen in obesity, may boost metabolism by stimulating thermogenesis and also reduce hunger and appetite. ^{[citation needed]}

Cold Thermogenesis is the process by which Brown adipose tissue "brown fat" is activated by cold. It was first advocated by NASA engineer Ray Cornise Thermogenex. Cornise did the energy calculations and deduced there was more going on in cold water immersion than explained by Newton's Law of Cooling. Author Tim Ferriss in his book The_4-Hour_Body featured Cornise's discoveries. Nashville neurosurgeon Jack Kruse on his blog as well as paleo presentations has expanded on the cold thermogenesis protocols and claims it promotes immunity as well as fat loss. "Living an Optimized Life"

Although bodybuilding formulations comprise the most common use of thermogenics, the drugs are entering the mainstream dieting industry.

The "meat sweats" are a real thing (Blair and Ellison, 1998).^{[citation needed]}

External links

Thermogenesis at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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 As a significant component of the metabolic rate, thermogenesis can potentially be stimulated to increase energy expenditure and fat oxidation (see Blair and Ellison's study, "The Seven Laws of Thermogenesis" (1998)){{Citation needed|date=February 2012}}.   [[Thermogenics]] are commonly made up of [[ephedra]], [[bitter orange]], [[capsicum]], [[ginger]], [[guar gum]], and [[pyruvate]].{{Citation needed|date=February 2012}}  [[Caffeine]] and [[Epigallocatechin gallate|EGCG]], both found in [[green tea]], may increase thermogenesis regulated by [[catecholamine]]s such as norepinephrine.{{Citation needed|date=February 2012}}  Researchers are also investigating the possibility of increasing the amount of [[brown adipose tissue]] in the body, a site of thermogenesis. {{Citation needed|date=February 2012}}  [[Leptin]] infusions, being studied due to the leptin resistance seen in [[obesity]], may boost metabolism by stimulating thermogenesis and also reduce hunger and appetite. {{Citation needed|date=February 2012}}
-Cold Thermogenesis is the process by which Brown adipose tissue "brown fat" is activated by cold. It was first advocated by [[NASA]] engineer Ray Cornise [http://hypothermics.com/home/ ''Thermogenex'']. Cornise did the energy calculations and deduced there was more going on in cold water immersion than explained by [[Newton's Law of Cooling]]. Author [[Tim Ferriss]] in his book [[The_4-Hour_Body]] featured Cornise's discoveries. Nashville neurosurgeon [[Jack Kruse]] on his blog as well as paleo presentations has expanded on the cold thermogenesis protocols and claims it promotes immunity as well as fat loss. [http://jackkruse.com/ |"Living an Optimized Life"]
+Cold Thermogenesis is the process by which Brown adipose tissue "brown fat" is activated by cold. It was first advocated by [[NASA]] engineer Ray Cornise [http://hypothermics.com/home/ ''Thermogenex'']. Cornise did the energy calculations and deduced there was more going on in cold water immersion than explained by [[Newton's Law of Cooling]]. Author [[Tim Ferriss]] in his book [[The_4-Hour_Body]] featured Cornise's discoveries. Nashville neurosurgeon [[Jack Kruse]] on his blog as well as paleo presentations has expanded on the cold thermogenesis protocols and claims it promotes immunity as well as fat loss. [http://jackkruse.com/ "Living an Optimized Life"]
 Although [[bodybuilding]] formulations comprise the most common use of [[thermogenics]], the drugs are entering the mainstream [[dieting]] industry.