User:AlliDiaz/Bacteroides thetaiotaomicron
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Things to improve:
- fix awkwardness of reading and grammar
- find a researcher to read over page
- find researcher with pictures
- possibly make the lead larger (low priority)
- Expand on history (3)
- possibly add in a section about its evolution (it has evolved to changes in diet, etc.)
- Pathology: treatment, expansion on symptoms and treatment options
- Add pathophysiology
- Genome: more explanation, go in-depth with genome sequencing
- Add research section
- Define microbiota
- Finding more recent sources, updating (2)
- Check current sources (1)
- More pictures
- Add a citation for second sentence of metabolism section
- Add better source for last sentence of role in immune response section
Research
After its initial culture in 1912, B. thetaiotaomicron became a model microbe to understand the microbiota in the human gut.[1]
B. thetaiotaomicron was chosen as a model due to its ability to break down polysaccharides. This research has expanded the ability to understand Polysaccharide metabolism in other bacteria.[1]
-expand on how B. thetaiotaomicron protected against the affects of colitis.
LP needs to add more: Its fully sequenced genome allows B. thetaiotaomicron to undergo genetic manipulation for the purpose of research. The genome is altered to understand the host-bacteria interaction, and interactions with other microbes. (fix citation) One study applied complex genetic circuits and found that B. thetaiotaomicron could be engineered to maintain long-term storage of responses to environmental conditions. This could lead to the ability to monitor effects of surface polysaccharides, colonization, and overall gut health of the host. (fix citation)
More ideas to add to research section:
- find other cases of B. thetaiotaomicron affecting other microbes, if we've been able to learn about other microbes because of B. thetaiotaomicron
- symbiotic traits
- other therapeutic applications
- how exactly has research affected our understanding of other organisms
- gut health and diseases
- understanding community dynamics
- Biotechnology, development of new methods for biofuel production or deity interventions for gut health.
Pathophysiology
Bacteroides thetaiotaomicron is an anaerobic pathogen that tends to colonize the intestinal areas of humans and mice. B. thetaiotaomicron is a commensal auxotroph, meaning it acquires nutrients by synthesizing organic compounds. It is gram-negative and has the ability to grow outer membrane vesicles (OMV) on its surface which contributes to its immunity and stability.
brooke articles:
https://journals.asm.org/doi/10.1128/spectrum.04815-22
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282036/
allison articles:
https://www.tandfonline.com/doi/full/10.1080/10408398.2020.1803198#d1e185
https://link.springer.com/article/10.1007/s12275-022-1614-1
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30514-5
https://academic.oup.com/lambio/article/56/1/51/6699356
- ^ a b Ye, Meng; Yu, Juping; Shi, Xuexia; Zhu, Jingyi; Gao, Xiangdong; Liu, Wei (2021-11-30). "Polysaccharides catabolism by the human gut bacterium - Bacteroides thetaiotaomicron : advances and perspectives". Critical Reviews in Food Science and Nutrition. 61 (21): 3569–3588. doi:10.1080/10408398.2020.1803198. ISSN 1040-8398.