Ro60-0175

Ro60-0175
Identifiers
	IUPAC name (S)-6-Chloro-5-fluoro-1H-indole-2-propanamine;
CAS Number	169675-09-6 ;
PubChem CID	3045227;
IUPHAR/BPS	274;
ChemSpider	2308002;
UNII	YQP8J4N96A;
ChEBI	CHEBI:142183;
CompTox Dashboard (EPA)	DTXSID801028190 ;
ECHA InfoCard	100.189.524
Chemical and physical data
Formula	C11H12ClFN2
Molar mass	226.68 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@@H](Cn1ccc2c1cc(c(c2)F)Cl)N;
	InChI InChI=1S/C11H12ClFN2/c1-7(14)6-15-3-2-8-4-10(13)9(12)5-11(8)15/h2-5,7H,6,14H2,1H3/t7-/m0/s1; Key:XJJZQXUGLLXTHO-ZETCQYMHSA-N;
	(verify)

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Ro60-0175 is a drug developed by Hoffmann–La Roche, which has applications in scientific research.^[1]^[2] It acts as a potent and selective agonist for both the 5-HT_2B and 5-HT_2C serotonin receptor subtypes, with good selectivity over the closely related 5-HT_2A subtype, and little or no affinity at other receptors.^[3]^[4]

References

^ Quarta D, Naylor CG, Stolerman IP (August 2007). "The serotonin 2C receptor agonist Ro-60-0175 attenuates effects of nicotine in the five-choice serial reaction time task and in drug discrimination". Psychopharmacology. 193 (3): 391–402. doi:10.1007/s00213-007-0802-3. PMID 17473916. S2CID 21020653.
^ Fletcher PJ, Rizos Z, Sinyard J, Tampakeras M, Higgins GA (May 2008). "The 5-HT2C receptor agonist Ro60-0175 reduces cocaine self-administration and reinstatement induced by the stressor yohimbine, and contextual cues". Neuropsychopharmacology. 33 (6): 1402–12. doi:10.1038/sj.npp.1301509. PMID 17653111.
^ Porter RH, Benwell KR, Lamb H, Malcolm CS, Allen NH, Revell DF, et al. (September 1999). "Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells". British Journal of Pharmacology. 128 (1): 13–20. doi:10.1038/sj.bjp.0702751. PMC 1571597. PMID 10498829.
^ Damjanoska KJ, Muma NA, Zhang Y, D'Souza DN, Garcia F, Carrasco GA, et al. (March 2003). "Neuroendocrine evidence that (S)-2-(chloro-5-fluoro-indol- l-yl)-1-methylethylamine fumarate (Ro 60-0175) is not a selective 5-hydroxytryptamine(2C) receptor agonist". The Journal of Pharmacology and Experimental Therapeutics. 304 (3): 1209–16. doi:10.1124/jpet.102.043489. PMID 12604698. S2CID 23880629.

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[1] Quarta D, Naylor CG, Stolerman IP (August 2007). "The serotonin 2C receptor agonist Ro-60-0175 attenuates effects of nicotine in the five-choice serial reaction time task and in drug discrimination". Psychopharmacology. 193 (3): 391–402. doi:10.1007/s00213-007-0802-3. PMID 17473916. S2CID 21020653.

[2] Fletcher PJ, Rizos Z, Sinyard J, Tampakeras M, Higgins GA (May 2008). "The 5-HT2C receptor agonist Ro60-0175 reduces cocaine self-administration and reinstatement induced by the stressor yohimbine, and contextual cues". Neuropsychopharmacology. 33 (6): 1402–12. doi:10.1038/sj.npp.1301509. PMID 17653111.

[3] Porter RH, Benwell KR, Lamb H, Malcolm CS, Allen NH, Revell DF, et al. (September 1999). "Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells". British Journal of Pharmacology. 128 (1): 13–20. doi:10.1038/sj.bjp.0702751. PMC 1571597. PMID 10498829.

[4] Damjanoska KJ, Muma NA, Zhang Y, D'Souza DN, Garcia F, Carrasco GA, et al. (March 2003). "Neuroendocrine evidence that (S)-2-(chloro-5-fluoro-indol- l-yl)-1-methylethylamine fumarate (Ro 60-0175) is not a selective 5-hydroxytryptamine(2C) receptor agonist". The Journal of Pharmacology and Experimental Therapeutics. 304 (3): 1209–16. doi:10.1124/jpet.102.043489. PMID 12604698. S2CID 23880629.

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See also

References