TLR2

Toll-like receptor 2 also known as TLR2 is a protein that in humans is encoded by the TLR2 gene. TLR2 has also been designated as CD282 (cluster of differentiation 282). TLR2 is one of the toll-like receptors and plays a role in the immune system. TLR2 is a membrane protein, a receptor, which is expressed on the surface of certain cells and recognizes foreign substances and passes on appropriate signals to the cells of the immune system.

Function

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-κB.

KMFM Thanet

KMFM Thanet is an Independent Local Radio serving the Isle of Thanet and the surrounding areas in Kent, South East England. It is the Thanet region of the KMFM radio network (owned by the KM Group), containing local advertisements and sponsorships for the area amongst a countywide schedule of programming.

History

KMFM Thanet began life as Thanet Local Radio (TLR 107.2), founded by Alan Mackay, Ken Wills and Pete Willson (now station manager at Academy FM (Thanet)), and launching in January 1998 from studios at Margate harbour. The launch was not without drama - four months prior, the Radio Authority gave the station the green light on the licence after some alleged internal legal wrangles between the company's directors.

Pete Willson was the first voice on-air; the first song to be played was Take That's "Back For Good", with reggae star Pato Banton recording a special version of his duet with UB40, "Baby Come Back", for the station's launch. The station's line-up was largely unchanged for five years.

TLR10

Toll-like receptor 10 is a protein that in humans is encoded by the TLR10 gene. TLR10 has also been designated as CD290 (cluster of differentiation 290).

Function

The protein encoded by this gene is a member of the toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Its exact function is not known. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.

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Isle of Portland

Coordinates: 50°33′00″N 2°26′24″W / 50.550°N 2.440°W / 50.550; -2.440

The Isle of Portland is a limestone tied island, 6 kilometres (4 mi) long by 2.7 kilometres (1.7 mi) wide, in the English Channel. Portland is 8 kilometres (5 mi) south of the resort of Weymouth, forming the southernmost point of the county of Dorset, England. A barrier beach over which runs the A354 road connects it to Chesil Beach and the mainland. Portland and Weymouth together form the borough of Weymouth and Portland. The population of Portland is 12,400.

Portland is a central part of the Jurassic Coast, a World Heritage Site on the Dorset and east Devon coast, important for its geology and landforms. Its name is used for one of the British Sea Areas, and has been exported as the name of North American and Australian towns. Portland stone, famous for its use in British and world architecture, including St Paul's Cathedral and the United Nations Headquarters, continues to be quarried.

Portland Harbour, in between Portland and Weymouth, is one of the largest man-made harbours in the world. The harbour was made by the building of stone breakwaters between 1848 and 1905. From its inception it was a Royal Navy base, and played prominent roles during the First and Second World Wars; ships of the Royal Navy and NATO countries worked up and exercised in its waters until 1995. The harbour is now a civilian port and popular recreation area, and was used for the 2012 Olympic Games.

Portland, Connecticut

Portland is a town in Middlesex County, Connecticut, United States. The population was 8,732 at the 2000 census. The town center is listed as a census-designated place (CDP). It is situated across the Connecticut River from Middletown. Brownstone quarried in Portland was used in the construction of Hartford's Old State House in 1796. The vast majority of the brownstone buildings in Connecticut (see College Row at Wesleyan University and the Long Walk at Trinity College) as well as the famous brownstones in New York City were built with brownstone from Portland's quarries.

About half of the town's perimeter is made up of the Connecticut River. The town has eight marinas and boat clubs as well as three 18-hole golf courses.

History

The Wangunk tribe lived in the area prior to European settlement, and lived in Portland continuously throughout the settler period. Wangunk descendants still live in the area today. Their name referred to the bend in the Connecticut River which curves around half of the town's perimeter.

Portland (album)

Portland is a studio album by Kevin Burke and Mícheál Ó Domhnaill, released in 1982 by Green Linnet Records (SIF 1041). This is the second and final album by this duo who first played together with the popular Irish traditional group The Bothy Band.

Background

Mícheál Ó Domhnaill co-founded the popular Irish traditional group The Bothy Band in 1974, along with Paddy Glackin (fiddle), Matt Molloy (flute and tin whistle), Paddy Keenan (uilleann pipes and tin whistle), Dónal Lunny (bouzouki, guitar, and production), and his sister Tríona Ní Dhomhnaill (harpsichord, clavinet and vocals). Ó Domhnaill met Kevin Burke when Burke replaced Glackin in the Bothy Band in May 1976. In the five years the Bothy Band were together, they emerged as one of the most exciting groups in the history of Irish traditional music. Much of their repertoire was rooted in the traditional music of Ireland, and their enthusiasm and musical virtuosity set a standard for future Irish traditional performers. They recorded three studio albums during their brief career: The Bothy Band (1975), Old Hag You Have Killed Me (1976), and Out of the Wind – Into the Sun (1977). A live album After Hours was released in 1979, the year the group disbanded.