Peptic Ulcer Disease Pathophysiology Diagram

Peptic Ulcer Disease (PUD) is a term used to describe a group of ulcerative disorders that occurs in areas of the gastrointestinal tract that are exposed to acid-pepsin secretion. It is also described as a break, or ulceration, in the protective mucosal lining of the lower esophagus, stomach, or duodenum. PUD develops when there is an imbalance between mucosal protective factors and the erosive factors.

2022

Background In the setting of perforated pepticulcer (PPU) peritonitis, empiric antimicrobial therapy is initiated perioperatively and adapted according to the culture sensitivity. This attitude may reduce the incidence of postoperative complications. The aim of the study is to describe the microbiota found in the peritonitis due to a PPU, and to evaluate the predictors for bacterial or fungal infection. Material and methods We performed a single-centre, retrospective observational study of all consecutive patients who presented with PPU peritonitis and underwent emergent surgery in Saint Pierre University Hospital, Brussels, Belgium, between January 2013 and December 2020. The medical history, parameters at admission, bacterial culture, antibiotic resistance and postoperative outcomes were analysed. Results A total of 43 patients were included in the study. The microbiological culture rate was positive in 31% (13/43) patients, with presence of bacteria in 20.9% (9/43) and fungal inf...

Arquivos de Gastroenterologia, 2014

International Surgery Journal

Background: Perforated peptic ulcer is the most common cause among all causes of gastrointestinal tract perforation which is an emergency condition of the abdomen that requires early recognition and timely surgical management. Peptic ulcer perforation is associated significant morbidity and mortality. The aim of study is to evaluate the incidence, clinical presentation, management and outcomes of the patient with peptic ulcer perforation undergoing emergency laparotomy.Methods: This retrospective study includes 45 patients who were operated for perforated peptic ulcer peritonitis at Bundelkhand Medical College and Associated Hospital, Sagar from March 2015 to April 2017. Paediatric patients of age less than 14 years, patients presenting as recurrent perforation were excluded from the study. A detailed history, clinical presentation and routine investigations were done in all cases.Results: In the present study, most of the patients were male. Most of these patients presents with cli...

Acta Scientific Gastrointestinal Disorders, 2019

Peptic ulcer perforation is a life threatening complication of peptic ulcer disease (PUD). 10%-20% of patients with peptic ulcer will develop complications, only 2%-14% of the ulcers will perforate [1,8]. Perforation is one of the commonest causes of emergency hospitalization and surgery in peptic ulcer disease [1]. Perforated peptic ulcer is associated with short term mortality and morbidity in up to 30% and 50% of the patients. The incidence of perforated peptic ulcer is approximately 7-10 per 10.000 populations per year [2,3]. An estimated 2% to 10% of patients with PUD will present with perforation of the stomach or the duodenum in their lifetimes, with a disproportionately high risk for mortality in the elderly [4,5]. Acute perforations of the duodenum are estimated to occur in 2-10% of patients with PUD [7,54].

The Professional Medical Journal, 2019

Introduction: Peptic ulcer perforation is the most common surgical emergency and the leading cause of peritonitis with high morbidity and mortality in all age groups throughout world. It is more prevalent in developing countries than developed ones. Graham’s Patch/omentopexy for duodenal perforation and simple closure along with tissue biopsy for the gastric perforation are the procedures of choice respectively. Objectives: To detect the mode of presentation and the outcomes of surgical procedures along with prognosis in patients suffering from perforated peptic ulcer. Study Design: Cross sectional study. Place and Duration of Study: Surgical Department of Peoples University of Medical & Health Science for Women Nawabshah, From January 2016 to December 2017. Methodology: All patients were admitted through OPD/Emergency. Patients presented with peritonitis having history of peptic ulcer disease were studied. X Ray chest/ X Ray abdomen Erect showed pnemoperitonium. Laparotomy and prim...

2017

Background: Peptic ulcer perforation and secondary peritonitis forms one of the commonest and most important causes of acute abdominal emergency, which the general surgeon has to deal with. Knowledge of risk factors and clinical manifestations helps in avoiding and early identification, timely treatment of peptic perforations. So, we were prompted to study the aetiology and clinical manifestations of peptic ulcer perforation. Material and Methods: The present study consisted of 50 consecutive cases of perforated peptic ulcers admitted over a period of two years. All the cases were studied with respect to risk factors such as nonsteroidal anti-inflammatory drugs (NSAIDs) intake, addictions, comorbid conditions, clinical features at the time of presentation, radiological investigations and operative findings. Results: The commonest age group affected was adult population between 30-50 years. A total of 44 cases (88%) of perforated peptic ulcer gave history of eating spicy and chilly f...

Acta medica Indonesiana, 2009

Ulcer healing process is an intricate and active process including reconstruction process of mucosa through formation of granulation tissue. Granulation tissue formation takes place by means of formation of ulcer base, formation of blood vessel (angiogenesis) and re-establishment of glandular architecture. The process of granulation tissue formation on the ulcer base takes place 48-72 hours after ulceration process occurs. These three phases involve various genes grouped according to their activated time, i.e. the initial response genes, intermediate response gene and late response genes. Initial response genes are activated in 30 minutes to 2 hours time, e.g EGF-R, c-fos, c-jun, egr-1, Sp-1, TFF-2/SP. Intermediate response genes are activated for 6 hours to 2 days, eg EGF, bFGF, PDGF and VEGF. Late response genes are activated for 14 days, e.g. HGF, ITF, c-met/HGF-R.

Scientific Reports

Published: xx xx xxxx opeN Scientific RepoRts | (2019) 9:8683 | https://doi.org/10.1038/s41598-019-44893-x

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