Editorial Volume 5, Issue 5 pp 330—331

Figure 1. Metformin inhibits the activation of IKK kinases in senescent cells. The model proposes that metformin reduces ROS generation by mitochondria preventing the activation of IKK kinases a step that is ROS-sensitive. Metformin does not affect the activation of the interferon response in senescent cells suggesting that it modulates the senescence associated secretory phenotype in a way that reduces chronic inflammation but not tumor suppression.