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Crucial Details in DNA Repair Processes

Researchers at the University of Birmingham have discovered answers that offer detail to explain two distinct DNA repair pathways that have long been debated.

15 Apr 2025

Genetic Variants Offer Clues to Targeted Asthma Treatments

Genome wide association studies (GWAS) have identified hundreds of genome regions containing thousands of genetic variants associated with asthma, but it's still not clear which variants have an actual causal link to the disease.

11 Apr 2025

Japanese Researchers Develop New Assay to Detect Epigenetic Toxicity

Chemicals used as food preservatives, flavoring agents, dyes, pesticides, cosmetics, cleaners, and other industrial materials are being increasingly recognized as a health hazard.

11 Apr 2025

Scientists Capture Dynamic Process of Chromatin Remodeling in Action

Chromatin remodeling plays a vital role in gene regulation, affecting how DNA is accessed. Disruptions in this process can also lead to cancer and other diseases.

7 Apr 2025

How Chromosomes Shape Up for Cell Division

Among the many marvels of life is the cell’s ability to divide and thus enable organisms to grow and renew themselves.

26 Mar 2025

EMBL Scientists Observe DNA Looping Process in High Resolution

Among the many marvels of life is the cell's ability to divide and thus enable organisms to grow and renew themselves.

25 Mar 2025

UV Light Reshapes 3D Genome Structure, Altering DNA Repair and Gene Activity

Research shows UV radiation modifies 3D genome structure, affecting DNA damage response and gene activity, offering insights for cancer prevention strategies.

24 Mar 2025

Mitochondria Found to Control DNA Repair Protein and Delay Inflammaging

In humans and other multicellular organisms, cells multiply. This defining feature allows embryos to grow into adulthood, and enables the healing of the many bumps, bruises and scrapes along the way.

14 Mar 2025

CRISPR Unlocks ‘Sleeping’ Genes—A Potential Cure for Prader-Willi Syndrome?

CRISPR epigenome editing successfully reactivates silenced genes in Prader-Willi Syndrome, highlighting potential for targeted therapies in genetic disorders.

20 Feb 2025

New Atlas Maps How Aging Breast Tissue Contributes to Cancer Risk

Aging is a privilege, but it also brings risks-including an increased likelihood of developing age-related diseases including cancer.

14 Feb 2025

Exploring Chromatin's Resilience to Develop Anti-Aging Strategies

The process of aging in the body may be more resilient than previously believed, according to a new study.

4 Feb 2025

Generative AI Decodes the 3D Structure of DNA

Although the genetic sequence is the same in every cell in the body, only a subset of those genes is expressed by each cell.

3 Feb 2025

EpiBERT AI Model Reveals How Genes Are Regulated in Human Cells

A team of investigators from Dana-Farber Cancer Institute, The Broad Institute of MIT and Harvard, Google, and Columbia University have created an artificial intelligence model that can predict which genes are expressed in any type of human cell.

30 Jan 2025

GET Model Unveils Gene Regulation with Unmatched Accuracy Across Cell Types

GET, a novel computational model, accurately predicts gene activity by analyzing chromatin accessibility and DNA sequences across diverse human cell types.

20 Jan 2025

Arabidopsis Study Finds that Centromeres Call the Shots in Retrotransposon Integration

Centromeres play a crucial role in cell division, with CENH3 guiding retrotransposon Tal1 integration, revealing insights into genome evolution and stability.

10 Jan 2025

New Insights into Nuclear Lipid Droplets as Regulators of Aging and Metabolic Health

A new research perspective was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 22 on December 9, 2024, entitled "Nuclear lipid droplets: a novel regulator of nuclear homeostasis and aging."

8 Jan 2025

Zebrafish Protein Promotes Cardiac Repair in Mice

Researchers from the Hubrecht Institute's Bakkers group have used a zebrafish protein to successfully repair damaged mouse hearts.

3 Jan 2025

Study Reveals Mechanism Behind Retrotransposon Insertion in Centromeres

A joint research group team led by Sayuri Tsukahara and Tetsuji Kakutani of the University of Tokyo has clarified a mechanism of how retrotransposons, genetic elements that can "jump around" chromosomes and are known drivers of evolution, preferentially insert in the centromere.

2 Jan 2025

A revolutionary antibody approach to fight cancer by restoring cellular fitness

Ovarian cancer cells exploit cell competition by altering Flower protein isoforms in stromal cells, promoting tumor survival and potential therapeutic targets.

18 Dec 2024

Researchers Map DNA Repair Protein Activity in Human Cells

New research from the Kind Group at the Hubrecht Institute sheds light on how cells repair damaged DNA. For the first time, the team has mapped the activity of repair proteins in individual human cells.

22 Nov 2024