Bacterial mRNAs begin with a triphosphate on the first transcribed nucleotide, but RNase E, the endonuclease long thought to initiate mRNA decay in Escherichia coli, only works well on RNA with a ...

"It has become easier and less expensive to do these very large experiments, so we were able to examine thousands of genes at the same time," says RNA biologist Cornelia de Moor. Through lab ...

Efficient RNA interference in Caenorhabditis elegans ... First, secondary siRNA has a 5′ triphosphate, precluding cloning methods that rely on a single 5′ phosphate. This explains the apparent ...

and uridine triphosphate (UTP). These nucleotides can then be further processed to form the pyrimidine bases found in DNA and RNA. The pyrimidine biosynthetic pathway is tightly regulated to ensure ...

while in RNA, it pairs with uracil (U). Adenine is also a component of important biomolecules such as ATP (adenosine triphosphate), which is the primary energy currency in cells. Guanine is another ...