Human leukocyte antigen - Wikipedia
HLA region of Chromosome 6. The human leukocyte antigen (HLA) system is a complex of genes on chromosome 6 in humans that encode cell-surface proteins responsible for regulation of the immune system. [1] The HLA system is also known as the human version of the major histocompatibility complex (MHC) found in many animals. [2]
Major histocompatibility complex: Antigen processing and …
Jul 18, 2013 · Map of the human HLA. The complex is conventionally divided into three regions: I, II, and III. Each region contains numerous loci (genes), only some of which are shown. Abbreviations: tapasin (TAPBP); large multifunctional proteases 1 and 2 (LMP1 and (more...)
Human Leukocyte Antigen (HLA) System - The Merck Manuals
The heavy chain consists of 2 peptide-binding domains, an immunoglobulin (Ig)-like domain, and a transmembrane region with a cytoplasmic tail. The heavy chain of the class I molecule is encoded by genes at HLA-A, HLA-B, and HLA-C loci.
The HLA System: Genetics, Immunology, Clinical Testing, and …
The human major histocompatibility complex HLA is located on the short arm of chromosome 6. It is known to be the most polymorphic genetic system in humans. The biological role of the HLA class I and class II molecules is to present processed ...
The HLA Region and Autoimmune Disease: Associations and …
The MHC, also known in humans as the human leukocyte antigen (HLA) region, encompasses 7.6Mb on chromosome 6p21 and is the most gene dense region within the human genome encoding 252 expressed loci including several key immune response genes.
The HLA genomic loci map: expression, interaction, diversity and ...
Jan 9, 2009 · The human leukocyte antigen (HLA) super-locus is a genomic region in the chromosomal position 6p21 that encodes the six classical transplantation HLA genes and at least 132 protein coding genes...
Genetics, Human Major Histocompatibility Complex (MHC)
Aug 14, 2023 · The HLA (human leukocyte antigens) complex is located on the short arm of chromosome 6.[1][2][3] The HLA genes follow the principles of Mendelian genetics and the encoded antigens are co-dominantly expressed on the cell surface.
Biochemistry, HLA Antigens - StatPearls - NCBI Bookshelf
Apr 24, 2023 · Human leukocyte antigens (HLA) are genes in major histocompatibility complexes (MHC) that help code for proteins that differentiate between self and non-self. They play a significant role in disease and immune defense. They are beneficial to the immune system but can also have detrimental effects.
Human Leukocyte Antigen - an overview | ScienceDirect Topics
Human leukocyte antigen (HLA) is a highly polymorphic region in the human genome and located at chromosome 6. It is a complex set of genes that encode proteins and involved in antigen presentation (Wieczorek et al., 2017).
Human Leukocyte Antigen - an overview | ScienceDirect Topics
Human Leukocyte Antigen (HLA) is a crucial component of antigen presentation that influences the susceptibility and severity of diseases like COVID-19 by affecting immune responses.