This report details the case of a 17-month old boy with refractory multifocal pyoderma gangrenosum responsive to anti-TNF therapy.

Adolescent risk-taking behavior has been associated with age-related changes in striatal activation to incentives. Previous cross-sectional studies have shown both increased and decreased striatal activation to incentives for adolescents compared to adults. The monetary incentive delay (MID) task, designed to assess functional brain activation in anticipation of reward, has been used extensively to examine striatal activation in both adult and adolescent populations. The current study used this task with a longitudinal approach across mid-adolescence and late adolescence/early adulthood. Twenty-two participants (13 male) were studied using the MID task at two time-points, once in mid-adolescence (mean age=16.11; SD=1.44) and a second time in late adolescence/early adulthood (mean age=20.14; SD=.67). Results revealed greater striatal activation with increased age in high- compared to low-incentive contexts (incentive magnitude), for gain as well as for loss trials (incentive valence). Results extend cross-sectional findings and show reduced striatal engagement in adolescence compared to adulthood during preparation for action in an incentive context.

Behavioral inhibition (BI) is an important early childhood marker of risk for later psychiatric problems. The current 20-year prospective, longitudinal study focused on individual differences in this early temperament and adolescent brain function. As adolescents, 83 participants initially identified in infancy with the temperament of BI were assessed using functional imaging to examine striatal responses to incentives. Five years later, as young adults, these participants provided self-report of their substance use. Our findings show that children's early temperament interacts with their striatal sensitivity to incentives in adolescence to predict their level of substance use in young adulthood. Those young adults who, as children, showed the highest levels of BI reported the greatest substance use if, as adolescents, they also exhibited striatal hypersensitivity to incentives. These longitudinal data delineate one developmental pathway involving early biology and brain mechanisms for substance use in young adulthood.

The results of a search for the top squark, the supersymmetric partner of the top quark, in final states with one isolated electron or muon, jets, and missing transverse momentum are reported. The search uses the 2015 LHC pp collision data at a center-of-mass energy of s=13 TeV recorded by the ATLAS detector and corresponding to an integrated luminosity of 3.2 fb-1. The analysis targets two types of signal models: gluino-mediated pair production of top squarks with a nearly mass-degenerate top squark and neutralino and direct pair production of top squarks, decaying to the top quark and the lightest neutralino. The experimental signature in both signal scenarios is similar to that of a top quark pair produced in association with large missing transverse momentum. No significant excess over the Standard Model background prediction is observed, and exclusion limits on gluino and top squark masses are set at 95% confidence level. The results extend the LHC run-1 exclusion limit on the gluino mass up to 1460 GeV in the gluino-mediated scenario in the high gluino and low top squark mass region and add an excluded top squark mass region from 745 to 780 GeV for the direct top squark model with a massless lightest neutralino. The results are also reinterpreted to set exclusion limits in a model of vectorlike top quarks.