Electricity and water systems in the Western US (WUS) are closely connected, with hydropower comprising 20% of total annual WUS generation, and electricity related to water comprising about 7% of total WUS electricity use. Because of these interdependencies, the threat of climate change to WUS resources will likely have compounding electricity impacts on the Western Interconnect grid. This study describes a WUS-wide water system model with a particular emphasis on estimating climate impacts on hydropower generation and water-related electricity use, which can be linked with a grid expansion model to support climate-resilient electricity planning. The water system model combines climatically-driven physical hydrology and management of both water supply and demand allocation, and is applied to an ensemble of 15 climate scenarios out to 2050. Model results show decreasing streamflow in key basins of the WUS under most scenarios. Annual water-related electricity use increases up to 4%, and by up to 6% during the summer months, driven by growing agricultural demands met increasingly through a shift toward energy-intensive groundwater to replace declining surface water. Total annual hydropower generation changes by +5% to −20% by mid-century but declines in most scenarios, with decreases in summer generation by up to nearly −30%. Water-related electricity use increases tend to coincide with hydropower generation declines, annually and seasonally, demonstrating the importance of concurrently evaluating the climate signal on both water-for-energy and energy-for-water to inform planning for grid reliability and decarbonization goals.