© 2019. The American Astronomical Society. All rights reserved. Located at Dome A, the highest point of the Antarctic plateau, the Chinese Kunlun station is considered to be one of the best ground-based photometric sites because of its extremely cold, dry, and stable atmosphere. A target can be monitored from there for over 40 days without diurnal interruption during a polar winter. This makes Kunlun station a perfect site to search for short-period transiting exoplanets. Since 2008, an observatory has existed at Kunlun station, and three telescopes are working there. Using these telescopes, the AST3 project has been carried out over the last 6 yr with a search for transiting exoplanets as one of its key programs (CHESPA). In the austral winters of 2016 and 2017, a set of target fields in the southern continuous viewing zone (CVZ) of TESS were monitored by the AST3-II telescope. In this paper, we introduce the CHESPA and present the first data release containing photometry of 26,578 bright stars (). The best photometric precision at the optimum magnitude for the survey is around 2 mmag. To demonstrate the data quality, we also present a catalog of 221 variables with a brightness variation greater than 5 mmag from the 2016 data. Among these variables, 179 are newly identified periodic variables not listed in the AAVSO database (https://www.aavso.org/), and 67 are listed in the Candidate Target List. These variables will require careful attention to avoid false-positive signals when searching for transiting exoplanets. Dozens of new transiting exoplanet candidates will be released in a subsequent paper.

© 2019. The American Astronomical Society. All rights reserved. We report first results from the CHinese Exoplanet Searching Program from Antarctica (CHESPA) - a wide-field high-resolution photometric survey for transiting exoplanets carried out using telescopes of the AST3 (Antarctic Survey Telescopes times 3) project. There are now three telescopes (AST3-I, AST3-II, and CSTAR-II) operating at Dome A - the highest point on the Antarctic Plateau - in a fully automatic and remote mode to exploit the superb observing conditions of the site, and its long and uninterrupted polar nights. The search for transiting exoplanets is one of the key projects for AST3. During the austral winters of 2016 and 2017 we used the AST3-II telescope to survey a set of target fields near the southern ecliptic pole, falling within the continuous viewing zone of the TESS mission. The first data release of the 2016 data, including images, catalogs, and light curves of 26,578 bright stars (), was presented in Zhang et al. The best precision, as measured by the rms of the light curves at the optimum magnitude of the survey (), is around 2 mmag. We detect 222 objects with plausible transit signals from these data, 116 of which are plausible transiting exoplanet candidates according to their stellar properties as given by the TESS Input Catalog, Gaia DR2, and TESS-HERMES spectroscopy. With the first data release from TESS expected in late 2018, this candidate list will be timely for improving the rejection of potential false-positives.

Introduction

There is conflicting evidence whether high-density lipoprotein cholesterol (HDL-C) is a risk factor for Alzheimer's disease (AD) and dementia. Genetic variation in the cholesteryl ester transfer protein (CETP) locus is associated with altered HDL-C. We aimed to assess AD risk by genetically predicted HDL-C.

Methods

Ten single nucleotide polymorphisms within the CETP locus predicting HDL-C were applied to the International Genomics of Alzheimer's Project (IGAP) exome chip stage 1 results in up 16,097 late onset AD cases and 18,077 cognitively normal elderly controls. We performed instrumental variables analysis using inverse variance weighting, weighted median, and MR-Egger.

Results

Based on 10 single nucleotide polymorphisms distinctly predicting HDL-C in the CETP locus, we found that HDL-C was not associated with risk of AD (P > .7).

Discussion

Our study does not support the role of HDL-C on risk of AD through HDL-C altered by CETP. This study does not rule out other mechanisms by which HDL-C affects risk of AD.